biostudies-literatureObluchinskaya EDThe Ministry of Science and Higher Education of the Russian Federation within the framework of the Government Assignment to the Murmansk Marine Biological Institute Russian Academy of Sciences606https://www.ebi.ac.uk/biostudies/studies/S-EPMC9605532biostudies-literatureUnknown20(10)This study aimed to compare the anti-inflammatory effects of fucoidans from brown seaweeds (<i>Saccharina japonica</i> (SJ), <i>Fucus vesiculosus</i> (FV), <i>Fucus distichus</i> (FD), <i>Fucus serratus</i> (FS), and <i>Ascophyllum nodosum</i> (AN)), and determine the relationship between composition and biological activity. The anti-inflammatory activity was tested in vitro. It is believed that inflammation could be triggered by free radicals. Fucoidans from <i>F. vesiculosus</i> (FV1 and FV3) showed the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with an IC₅₀ = 0.05 mg/mL. In the total antioxidant capacity (TAC) test, the activity was concentration-dependent. Notable, the TAC of fucoidans except samples of FV2 and SJ (which have a lower phenolic Marine drugsIn Vitro Anti-Inflammatory Activities of Fucoidans from Five Species of Brown Seaweeds.PMC9605532121091600104-7Obluchinskaya EDPozharitskaya ONShikov ANfalseIn Vitro Anti-Inflammatory Activities of Fucoidans from Five Species of Brown Seaweeds.This study aimed to compare the anti-inflammatory effects of fucoidans from brown seaweeds (<i>Saccharina japonica</i> (SJ), <i>Fucus vesiculosus</i> (FV), <i>Fucus distichus</i> (FD), <i>Fucus serratus</i> (FS), and <i>Ascophyllum nodosum</i> (AN)), and determine the relationship between composition and biological activity. The anti-inflammatory activity was tested in vitro. It is believed that inflammation could be triggered by free radicals. Fucoidans from <i>F. vesiculosus</i> (FV1 and FV3) showed the strongest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity with an IC₅₀ = 0.05 mg/mL. In the total antioxidant capacity (TAC) test, the activity was concentration-dependent. Notable, the TAC of fucoidans except samples of FV2 and SJ (which have a lower phenolic 2022-01-01T00:00:00Z2022 Sep2025-04-26T10:45:43.846Z2025-04-06T13:28:45.687ZS-EPMC96055323628643010.3390/md20100606