biostudies-literatureAn KMKorea Research Institute of Standards and ScienceCollaborative Research Program of the Collaborative Research Network for Asian Children with Developmental DisordersCenter of Innovation ProgramBK21 FOUR programSamsung research funding and incubation center of Samsung electronicsMinistry of Education of the Republic of Korea and the National Research Foundation of Korea17993https://www.ebi.ac.uk/biostudies/studies/S-EPMC9606299biostudies-literatureUnknown12(1)Magnetoencephalography (MEG) is a functional neuroimaging technique that noninvasively detects the brain magnetic field from neuronal activations. Conventional MEG measures brain signals using superconducting quantum interference devices (SQUIDs). SQUID-MEG requires a cryogenic environment involving a bulky non-magnetic Dewar flask and the consumption of liquid helium, which restricts the variability of the sensor array and the gap between the cortical sources and sensors. Recently, miniature optically pumped magnetometers (OPMs) have been developed and commercialized. OPMs do not require cryogenic cooling and can be placed within millimeters from the scalp. In the present study, we arranged six OPM sensors on the temporal area to detect auditory-related brain responses in a two-layer magnScientific reportsDetection of the 40 Hz auditory steady-state response with optically pumped magnetometers.PMC9606299SRFC-IT2101-07NRF-2021R1A2C2094578GP2021-0010Iwasaki SAn KMShim JHKwon MHirosawa TKikuchi MHasegawa CChun WYKim KLee YHKwon HYu KKfalseDetection of the 40 Hz auditory steady-state response with optically pumped magnetometers.Magnetoencephalography (MEG) is a functional neuroimaging technique that noninvasively detects the brain magnetic field from neuronal activations. Conventional MEG measures brain signals using superconducting quantum interference devices (SQUIDs). SQUID-MEG requires a cryogenic environment involving a bulky non-magnetic Dewar flask and the consumption of liquid helium, which restricts the variability of the sensor array and the gap between the cortical sources and sensors. Recently, miniature optically pumped magnetometers (OPMs) have been developed and commercialized. OPMs do not require cryogenic cooling and can be placed within millimeters from the scalp. In the present study, we arranged six OPM sensors on the temporal area to detect auditory-related brain responses in a two-layer magn2022-01-01T00:00:00Z2022 Oct2025-04-22T05:40:39.29Z2025-04-05T21:24:16.461ZS-EPMC96062993628926710.1038/s41598-022-21870-5