{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Pedersen KJ"],"funding":["Novo Nordisk Foundation","Helmholtz Centre for Environmental Research","DFG, German Research Foundation","UFZ for the ProMetheus platform for proteomics and metabolomics","German Research Foundation (DFG)"],"pagination":["2025"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9607062"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(10)"],"pubmed_abstract":["Bile acids are crucial for the uptake of dietary lipids and can shape the gut-microbiome composition. This latter function is associated with the toxicity of bile acids and can be modulated by bile acid modifying bacteria such as <i>Eggerthella lenta</i>, but the molecular details of the interaction of bacteria depending on bile acid modifications are not well understood. In order to unravel the molecular response to bile acids and their metabolites, we cultivated eight strains from a human intestinal microbiome model alone and in co-culture with <i>Eggerthella lenta</i> in the presence of cholic acid (CA) and deoxycholic acid (DCA). We observed growth inhibition of particularly gram-positive strains such as <i>Clostridium ramosum</i> and the gram-variable Anaerostipes cacae by CA and DCA "],"journal":["Microorganisms"],"pubmed_title":["<i>Eggerthella lenta</i> DSM 2243 Alleviates Bile Acid Stress Response in <i>Clostridium ramosum</i> and <i>Anaerostipes caccae</i> by Transformation of Bile Acids."],"pmcid":["PMC9607062"],"funding_grant_id":["403224013–SFB 1382","NNF21OC0066551","Project-ID 403224013 - SFB 1382","SFB 1382 - A05"],"pubmed_authors":["Zizalova K","Viehof A","Schaap FG","Rolle-Kampczyk U","Pedersen KJ","Lenicek M","Engelmann B","Haange SB","von Bergen M","Wick LY","Clavel T","Jehmlich N"],"additional_accession":[]},"is_claimable":false,"name":"<i>Eggerthella lenta</i> DSM 2243 Alleviates Bile Acid Stress Response in <i>Clostridium ramosum</i> and <i>Anaerostipes caccae</i> by Transformation of Bile Acids.","description":"Bile acids are crucial for the uptake of dietary lipids and can shape the gut-microbiome composition. This latter function is associated with the toxicity of bile acids and can be modulated by bile acid modifying bacteria such as <i>Eggerthella lenta</i>, but the molecular details of the interaction of bacteria depending on bile acid modifications are not well understood. In order to unravel the molecular response to bile acids and their metabolites, we cultivated eight strains from a human intestinal microbiome model alone and in co-culture with <i>Eggerthella lenta</i> in the presence of cholic acid (CA) and deoxycholic acid (DCA). We observed growth inhibition of particularly gram-positive strains such as <i>Clostridium ramosum</i> and the gram-variable Anaerostipes cacae by CA and DCA ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-26T12:01:38.062Z","creation":"2025-04-06T13:52:21.004Z"},"accession":"S-EPMC9607062","cross_references":{"pubmed":["36296301"],"doi":["10.3390/microorganisms10102025"]}}