{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Calvo-Lozano O"],"funding":["Consiglio Nazionale delle Ricerche","Generalitat de Catalunya","European Social Fund","Competitivity Operational Program","Ministerio de Ciencia e Innovaci?n","Agencia Estatal de Investigaci?n"],"pagination":["14659-14665"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9607850"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["94(42)"],"pubmed_abstract":["The rapid diagnosis of cancer, especially in its early stages, is crucial for on-time medical treatment and for increasing the patient survival rate. Lung cancer shows the highest mortality rate and the lowest 5-year survival rate due to the late diagnosis in advanced cancer stages. Providing rapid and reliable diagnostic tools is a top priority to address the problem of a delayed cancer diagnosis. We introduce a nanophotonic biosensor for the direct and real-time detection in human plasma of the microRNA-21-5p biomarker related to lung cancer. The biosensor employs a silicon photonic bimodal interferometric waveguide that provides a highly sensitive detection in a label-free format. We demonstrate a very competitive detectability for direct microRNA-21-5p biomarker assays in human plasma "],"journal":["Analytical chemistry"],"pubmed_title":["One-Step and Real-Time Detection of microRNA-21 in Human Samples for Lung Cancer Biosensing Diagnosis."],"pmcid":["PMC9607850"],"funding_grant_id":["SEV-2017-0706","POC-P_37_796/2016","PCI2019-111890-2","PID2019-105132RB-I00","BES-2017-080527","TEC2016-78515-R"],"pubmed_authors":["Estevez MC","Calvo-Lozano O","Garcia-Aparicio P","Berindan-Neagoe I","Ferracin M","Lechuga LM","Raduly LZ"],"additional_accession":[]},"is_claimable":false,"name":"One-Step and Real-Time Detection of microRNA-21 in Human Samples for Lung Cancer Biosensing Diagnosis.","description":"The rapid diagnosis of cancer, especially in its early stages, is crucial for on-time medical treatment and for increasing the patient survival rate. Lung cancer shows the highest mortality rate and the lowest 5-year survival rate due to the late diagnosis in advanced cancer stages. Providing rapid and reliable diagnostic tools is a top priority to address the problem of a delayed cancer diagnosis. We introduce a nanophotonic biosensor for the direct and real-time detection in human plasma of the microRNA-21-5p biomarker related to lung cancer. The biosensor employs a silicon photonic bimodal interferometric waveguide that provides a highly sensitive detection in a label-free format. We demonstrate a very competitive detectability for direct microRNA-21-5p biomarker assays in human plasma ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-05-18T11:38:36.313Z","creation":"2025-05-18T11:38:36.313Z"},"accession":"S-EPMC9607850","cross_references":{"pubmed":["36219565"],"doi":["10.1021/acs.analchem.2c02895"]}}