{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Yang JY"],"pubmed_abstract":["Abdominal irradiation (IR) destroys the intestinal mucosal barrier, leading to severe intestinal infection. There is an urgent need to find safe and effective treatments to reduce IR-induced intestinal injury. In this study, we reported that metformin protected mice from abdominal IR-induced intestinal injury by improving the composition and diversity of intestinal flora. The elimination of intestinal microbiota (Abx) abrogated the protective effects of metformin on irradiated mice. We further characterized that treatment of metformin increased the murine intestinal abundance of <i>Lactobacillus</i>, which mediated the radioprotective effect. The administration of <i>Lactobacillus</i> or fecal microbiota transplantation (FMT) into Abx mice considerably lessened IR-induced intestinal damage"],"journal":["Frontiers in microbiology"],"pagination":["932294"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9608595"],"repository":["biostudies-literature"],"pubmed_title":["Metformin alleviates irradiation-induced intestinal injury by activation of FXR in intestinal epithelia."],"pmcid":["PMC9608595"],"pubmed_authors":["Yang JY","Liu GL","Zhang H","Liu MJ","Jian YP","Cui CY","Ding Q","Guo JR","Xu ZX","Lv L","He KY","Yan BZ","Wang JH","Wang KK","Du DD"],"additional_accession":[]},"is_claimable":false,"name":"Metformin alleviates irradiation-induced intestinal injury by activation of FXR in intestinal epithelia.","description":"Abdominal irradiation (IR) destroys the intestinal mucosal barrier, leading to severe intestinal infection. There is an urgent need to find safe and effective treatments to reduce IR-induced intestinal injury. In this study, we reported that metformin protected mice from abdominal IR-induced intestinal injury by improving the composition and diversity of intestinal flora. The elimination of intestinal microbiota (Abx) abrogated the protective effects of metformin on irradiated mice. We further characterized that treatment of metformin increased the murine intestinal abundance of <i>Lactobacillus</i>, which mediated the radioprotective effect. The administration of <i>Lactobacillus</i> or fecal microbiota transplantation (FMT) into Abx mice considerably lessened IR-induced intestinal damage","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-22T02:01:33.337Z","creation":"2025-04-22T02:01:33.337Z"},"accession":"S-EPMC9608595","cross_references":{"pubmed":["36312920"],"doi":["10.3389/fmicb.2022.932294"]}}