{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tuzun-Antepli B"],"funding":["Scientific and Technological Research Council of Turkey"],"pagination":["7091"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9609095"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(20)"],"pubmed_abstract":["The content and surface topology of tissue engineering scaffolds are two important parameters in regulating the cell behavior. In this study, a phase separation micromolding (PSµM) method was implemented to develop micro-groove-imprinted poly(ε-caprolactone) (PCL)-nano hydroxyapatite (nHAp)-reduced graphene oxide (rGO) ternary blend constructs. Physical and chemical characterizations of cell-devoid constructs were performed by FTIR, XRD, TGA, DSC, porosity, swelling, wettability analysis, tensile and compression mechanical tests. The in vitro biological performance of human osteoblasts cultured on micro-patterned blend constructs was evaluated by MTT and alamarBlue viability assays. The findings revealed that nHAp and rGO significantly promote cell viability and proliferation, while the mi"],"journal":["Molecules (Basel, Switzerland)"],"pubmed_title":["Evaluation of Human Osteoblasts on NIPS Micro-Patterned PCL Carriers Containing Nanohydroxyapatite and Reduced Graphene Oxide Using PSµM."],"pmcid":["PMC9609095"],"funding_grant_id":["119N136"],"pubmed_authors":["Tuzun-Antepli B","Khang G","Seker S","Elcin AE","Elcin YM"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of Human Osteoblasts on NIPS Micro-Patterned PCL Carriers Containing Nanohydroxyapatite and Reduced Graphene Oxide Using PSµM.","description":"The content and surface topology of tissue engineering scaffolds are two important parameters in regulating the cell behavior. In this study, a phase separation micromolding (PSµM) method was implemented to develop micro-groove-imprinted poly(ε-caprolactone) (PCL)-nano hydroxyapatite (nHAp)-reduced graphene oxide (rGO) ternary blend constructs. Physical and chemical characterizations of cell-devoid constructs were performed by FTIR, XRD, TGA, DSC, porosity, swelling, wettability analysis, tensile and compression mechanical tests. The in vitro biological performance of human osteoblasts cultured on micro-patterned blend constructs was evaluated by MTT and alamarBlue viability assays. The findings revealed that nHAp and rGO significantly promote cell viability and proliferation, while the mi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-22T05:41:20.534Z","creation":"2025-04-05T21:24:33.15Z"},"accession":"S-EPMC9609095","cross_references":{"pubmed":["36296680"],"doi":["10.3390/molecules27207091"]}}