biostudies-literatureChao YMMinistry of Science and TechnologyMinistry of Science and Technology, TaiwanKaohsiung Chang Gung Memorial HospitalChang Gung Medical Foundation4306https://www.ebi.ac.uk/biostudies/studies/S-EPMC9609147biostudies-literatureUnknown14(20)The role of short-chain fatty acids (SCFAs) in the brain on the developmental programming of hypertension is poorly understood. The present study explored dysregulated tissue levels of SCFAs and expression of SCFA-sensing receptors in the hypothalamic paraventricular nucleus (PVN), a key forebrain region engaged in neural regulation of blood pressure of offspring to maternal high fructose diet (HFD) exposure. We further investigated the engagement of SCFA-sensing receptors in PVN in the beneficial effects of -biotics (prebiotic, probiotic, synbiotic, and postbiotic) on programmed hypertension. Maternal HFD during gestation and lactation significantly reduced circulating butyrate, along with decreased tissue level of butyrate and increased expression of SCFA-sensing receptors, GPR41 and olfNutrientsProtection by -Biotics against Hypertension Programmed by Maternal High Fructose Diet: Rectification of Dysregulated Expression of Short-Chain Fatty Acid Receptors in the Hypothalamic Paraventricular Nucleus of Adult Offspring.PMC9609147CMRPG8J0261-263.CLRPG8J0031-0032MOST109-2320-B-182A-006; MOST110-2320-B-182A-020CMRPG8J0261-0263MOST110-2320-B-182A-020MOST111-2320-B-182A-015MOST109-2320-B-182A-006Chan JYHChao YMWu KLHYu HRTain YLLee WCfalseProtection by -Biotics against Hypertension Programmed by Maternal High Fructose Diet: Rectification of Dysregulated Expression of Short-Chain Fatty Acid Receptors in the Hypothalamic Paraventricular Nucleus of Adult Offspring.The role of short-chain fatty acids (SCFAs) in the brain on the developmental programming of hypertension is poorly understood. The present study explored dysregulated tissue levels of SCFAs and expression of SCFA-sensing receptors in the hypothalamic paraventricular nucleus (PVN), a key forebrain region engaged in neural regulation of blood pressure of offspring to maternal high fructose diet (HFD) exposure. We further investigated the engagement of SCFA-sensing receptors in PVN in the beneficial effects of -biotics (prebiotic, probiotic, synbiotic, and postbiotic) on programmed hypertension. Maternal HFD during gestation and lactation significantly reduced circulating butyrate, along with decreased tissue level of butyrate and increased expression of SCFA-sensing receptors, GPR41 and olf2022-01-01T00:00:00Z2022 Oct2025-04-18T21:22:47.412Z2025-04-07T09:15:47.566ZS-EPMC96091473629699110.3390/nu14204306