{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Quarta S"],"funding":["ESSECORE SRL","Esscore SRL, Bari, italy"],"pagination":["1263"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9609228"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(10)"],"pubmed_abstract":["Osteoarthritis (OA) is a joint disease characterized by inflammation of the synovium, angiogenesis, cartilage degradation, and osteophyte formation. <i>Harpagophytum Procumbens</i> DC. ex Meisn., <i>Boswellia Serrata</i> Roxb., <i>Curcuma longa</i> L., Bromelain and Escin (<i>Aesculus hippocastanum</i>) are plants which extracts, together to Bromelain and Escin (<i>Aesculus hippocastanum</i>) are traditionally used in OA. However, their mechanistic role remains unclear. We aimed to investigate whether these bioactives alone or in combination (as in Flonat Fast<sup>®</sup>) can suppress TNF-α-induced inflammation, angiogenesis, and osteophyte formation using two cell models involved in OA: endothelial cells and monocytes. Each plant extract was evaluated for its polyphenol content, antioxid"],"journal":["Pharmaceuticals (Basel, Switzerland)"],"pubmed_title":["Analysis of the Anti-Inflammatory and Anti-Osteoarthritic Potential of Flonat Fast<sup>®</sup>, a Combination of <i>Harpagophytum Procumbens</i> DC. ex Meisn., <i>Boswellia Serrata</i> Roxb., <i>Curcuma longa</i> L., Bromelain and Escin (<i>Aesculus hippocastanum</i>), Evaluated in In Vitro Models of Inflammation Relevant to Osteoarthritis."],"pmcid":["PMC9609228"],"funding_grant_id":["No grant number"],"pubmed_authors":["Damiano F","Verri T","Santarpino G","Carluccio MA","Scoditti E","Calabriso N","Siculella L","De Caterina R","Maffia M","Massaro M","Quarta S"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of the Anti-Inflammatory and Anti-Osteoarthritic Potential of Flonat Fast<sup>®</sup>, a Combination of <i>Harpagophytum Procumbens</i> DC. ex Meisn., <i>Boswellia Serrata</i> Roxb., <i>Curcuma longa</i> L., Bromelain and Escin (<i>Aesculus hippocastanum</i>), Evaluated in In Vitro Models of Inflammation Relevant to Osteoarthritis.","description":"Osteoarthritis (OA) is a joint disease characterized by inflammation of the synovium, angiogenesis, cartilage degradation, and osteophyte formation. <i>Harpagophytum Procumbens</i> DC. ex Meisn., <i>Boswellia Serrata</i> Roxb., <i>Curcuma longa</i> L., Bromelain and Escin (<i>Aesculus hippocastanum</i>) are plants which extracts, together to Bromelain and Escin (<i>Aesculus hippocastanum</i>) are traditionally used in OA. However, their mechanistic role remains unclear. We aimed to investigate whether these bioactives alone or in combination (as in Flonat Fast<sup>®</sup>) can suppress TNF-α-induced inflammation, angiogenesis, and osteophyte formation using two cell models involved in OA: endothelial cells and monocytes. Each plant extract was evaluated for its polyphenol content, antioxid","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-04-08T18:20:54.96Z","creation":"2025-04-19T04:23:53.592Z"},"accession":"S-EPMC9609228","cross_references":{"pubmed":["36297375"],"doi":["10.3390/ph15101263"]}}