biostudies-literatureQuarta SESSECORE SRLEsscore SRL, Bari, italy1263https://www.ebi.ac.uk/biostudies/studies/S-EPMC9609228biostudies-literatureUnknown15(10)Osteoarthritis (OA) is a joint disease characterized by inflammation of the synovium, angiogenesis, cartilage degradation, and osteophyte formation. <i>Harpagophytum Procumbens</i> DC. ex Meisn., <i>Boswellia Serrata</i> Roxb., <i>Curcuma longa</i> L., Bromelain and Escin (<i>Aesculus hippocastanum</i>) are plants which extracts, together to Bromelain and Escin (<i>Aesculus hippocastanum</i>) are traditionally used in OA. However, their mechanistic role remains unclear. We aimed to investigate whether these bioactives alone or in combination (as in Flonat Fast^®) can suppress TNF-α-induced inflammation, angiogenesis, and osteophyte formation using two cell models involved in OA: endothelial cells and monocytes. Each plant extract was evaluated for its polyphenol content, antioxidPharmaceuticals (Basel, Switzerland)Analysis of the Anti-Inflammatory and Anti-Osteoarthritic Potential of Flonat Fast^®, a Combination of <i>Harpagophytum Procumbens</i> DC. ex Meisn., <i>Boswellia Serrata</i> Roxb., <i>Curcuma longa</i> L., Bromelain and Escin (<i>Aesculus hippocastanum</i>), Evaluated in In Vitro Models of Inflammation Relevant to Osteoarthritis.PMC9609228No grant numberDamiano FVerri TSantarpino GCarluccio MAScoditti ECalabriso NSiculella LDe Caterina RMaffia MMassaro MQuarta SfalseAnalysis of the Anti-Inflammatory and Anti-Osteoarthritic Potential of Flonat Fast^®, a Combination of <i>Harpagophytum Procumbens</i> DC. ex Meisn., <i>Boswellia Serrata</i> Roxb., <i>Curcuma longa</i> L., Bromelain and Escin (<i>Aesculus hippocastanum</i>), Evaluated in In Vitro Models of Inflammation Relevant to Osteoarthritis.Osteoarthritis (OA) is a joint disease characterized by inflammation of the synovium, angiogenesis, cartilage degradation, and osteophyte formation. <i>Harpagophytum Procumbens</i> DC. ex Meisn., <i>Boswellia Serrata</i> Roxb., <i>Curcuma longa</i> L., Bromelain and Escin (<i>Aesculus hippocastanum</i>) are plants which extracts, together to Bromelain and Escin (<i>Aesculus hippocastanum</i>) are traditionally used in OA. However, their mechanistic role remains unclear. We aimed to investigate whether these bioactives alone or in combination (as in Flonat Fast^®) can suppress TNF-α-induced inflammation, angiogenesis, and osteophyte formation using two cell models involved in OA: endothelial cells and monocytes. Each plant extract was evaluated for its polyphenol content, antioxid2022-01-01T00:00:00Z2022 Oct2026-04-08T18:20:54.96Z2025-04-19T04:23:53.592ZS-EPMC96092283629737510.3390/ph15101263