{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Haß U"],"funding":["German Society for Nutritional Medicine","German Society for Nutritional Medicine (DGEM)"],"pagination":["4274"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9609960"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(20)"],"pubmed_abstract":["<h4>Background</h4>Inflammaging is considered to drive loss of muscle function. Omega-3 fatty acids exhibit anti-inflammatory properties. Therefore, we examined the effects of eight weeks of vibration and home-based resistance exercise combined with a whey-enriched, omega-3-supplemented diet on muscle power, inflammation and muscle biomarkers in community-dwelling old adults.<h4>Methods</h4>Participants were randomized to either exercise (3x/week, <i>n</i> = 20), exercise + high-protein diet (1.2-1.5 g/kg, <i>n</i> = 20), or exercise + high-protein and omega-3-enriched diet (2.2 g/day, <i>n</i> = 21). Muscle power (watt/m<sup>2</sup>) and chair rise test (CRT) time (s) were assessed via CRT measured with mechanography. Furthermore, leg strength (kg/m<sup>2</sup>) and fasting concentrations of inflammatory (interleukin (IL-) 6, IL-10, high-mobility group box-1 (HMGB-1)) and muscle biomarkers (insulin-like growth factor (IGF-) 1, IGF-binding protein-3, myostatin) were assessed.<h4>Results</h4>Sixty-one participants (70.6 ± 4.7 years; 47% men) completed the study. According to generalized linear mixed models, a high-protein diet improved leg strength and CRT time. Only IGF-1 increased with additional omega-3. Sex-specific analyses revealed that muscle power, IL-6, IL-6/IL-10 ratio, and HMGB-1 improved significantly in the male high-protein, omega-3-enriched group only.<h4>Conclusion</h4>Vibration and home-based resistance exercise combined with a high-protein, omega-3-enriched diet increased muscle power and reduced inflammation in old men, but not in old women. While muscle biomarkers remained unchanged, a high-protein diet combined with exercise improved leg strength and CRT time."],"journal":["Nutrients"],"pubmed_title":["Effects of an Omega-3 Supplemented, High-Protein Diet in Combination with Vibration and Resistance Exercise on Muscle Power and Inflammation in Old Adults: A Pilot Randomized Controlled Trial."],"pmcid":["PMC9609960"],"funding_grant_id":["DGEM research grant 2020","2020"],"pubmed_authors":["Norman K","Kochlik B","Herpich C","Rudloff S","Haß U"],"additional_accession":[]},"is_claimable":false,"name":"Effects of an Omega-3 Supplemented, High-Protein Diet in Combination with Vibration and Resistance Exercise on Muscle Power and Inflammation in Old Adults: A Pilot Randomized Controlled Trial.","description":"<h4>Background</h4>Inflammaging is considered to drive loss of muscle function. Omega-3 fatty acids exhibit anti-inflammatory properties. Therefore, we examined the effects of eight weeks of vibration and home-based resistance exercise combined with a whey-enriched, omega-3-supplemented diet on muscle power, inflammation and muscle biomarkers in community-dwelling old adults.<h4>Methods</h4>Participants were randomized to either exercise (3x/week, <i>n</i> = 20), exercise + high-protein diet (1.2-1.5 g/kg, <i>n</i> = 20), or exercise + high-protein and omega-3-enriched diet (2.2 g/day, <i>n</i> = 21). Muscle power (watt/m<sup>2</sup>) and chair rise test (CRT) time (s) were assessed via CRT measured with mechanography. Furthermore, leg strength (kg/m<sup>2</sup>) and fasting concentrations of inflammatory (interleukin (IL-) 6, IL-10, high-mobility group box-1 (HMGB-1)) and muscle biomarkers (insulin-like growth factor (IGF-) 1, IGF-binding protein-3, myostatin) were assessed.<h4>Results</h4>Sixty-one participants (70.6 ± 4.7 years; 47% men) completed the study. According to generalized linear mixed models, a high-protein diet improved leg strength and CRT time. Only IGF-1 increased with additional omega-3. Sex-specific analyses revealed that muscle power, IL-6, IL-6/IL-10 ratio, and HMGB-1 improved significantly in the male high-protein, omega-3-enriched group only.<h4>Conclusion</h4>Vibration and home-based resistance exercise combined with a high-protein, omega-3-enriched diet increased muscle power and reduced inflammation in old men, but not in old women. While muscle biomarkers remained unchanged, a high-protein diet combined with exercise improved leg strength and CRT time.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2024-10-19T01:42:56.974Z","creation":"2024-10-19T01:42:56.974Z"},"accession":"S-EPMC9609960","cross_references":{"pubmed":["36296958"],"doi":["10.3390/nu14204274"]}}