{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zha F"],"funding":["Qingping Wu"],"pagination":["2084"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9610228"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(10)"],"pubmed_abstract":["Small non-coding RNAs (sRNAs) in bacteria are important regulatory molecules for controlling virulence. In <i>Vibrio</i> spp., Qrr sRNAs are critical for quorum-sensing pathways and regulating the release of some virulence factors. However, the detailed role of Qrr sRNAs in the virulence of <i>Vibrio</i>&amp;nbsp;<i>parahaemolyticus</i> remains poorly understood. In this study, we identified a <i>Vibrio</i> sRNA <i>Qrr5</i> that positively regulates cytotoxicity and adherence in Caco-2 cells by primarily regulating the T3SS1 gene cluster. A number of 185, 586, 355, and 74 differentially expressed genes (DEGs) detected at 0, 2, 4, and 6 h post-infection, respectively, were mainly associated with ABC transporters and two-component system pathways. The DEGs exhibited a dynamic change in expre"],"journal":["Microorganisms"],"pubmed_title":["Gene Regulatory Network of the Noncoding RNA <i>Qrr5</i> Involved in the Cytotoxicity of <i>Vibrio parahaemolyticus</i> during Infection."],"pmcid":["PMC9610228"],"funding_grant_id":["31730070"],"pubmed_authors":["Zhang J","Chen M","Wu Q","Yang M","Zhang H","Wang J","Pang R","Huang S","Ding Y","Ye Q","Wu S","Xue L","Zha F","Gu Q"],"additional_accession":[]},"is_claimable":false,"name":"Gene Regulatory Network of the Noncoding RNA <i>Qrr5</i> Involved in the Cytotoxicity of <i>Vibrio parahaemolyticus</i> during Infection.","description":"Small non-coding RNAs (sRNAs) in bacteria are important regulatory molecules for controlling virulence. In <i>Vibrio</i> spp., Qrr sRNAs are critical for quorum-sensing pathways and regulating the release of some virulence factors. However, the detailed role of Qrr sRNAs in the virulence of <i>Vibrio</i>&amp;nbsp;<i>parahaemolyticus</i> remains poorly understood. In this study, we identified a <i>Vibrio</i> sRNA <i>Qrr5</i> that positively regulates cytotoxicity and adherence in Caco-2 cells by primarily regulating the T3SS1 gene cluster. A number of 185, 586, 355, and 74 differentially expressed genes (DEGs) detected at 0, 2, 4, and 6 h post-infection, respectively, were mainly associated with ABC transporters and two-component system pathways. The DEGs exhibited a dynamic change in expre","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-05-29T14:37:09.624Z","creation":"2024-10-19T01:40:19.234Z"},"accession":"S-EPMC9610228","cross_references":{"pubmed":["36296357"],"doi":["10.3390/microorganisms10102084"]}}