{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tosar JP"],"funding":["NIDA NIH HHS","NIAID NIH HHS","NIMH NIH HHS","NCI NIH HHS"],"pagination":["e45"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9610496"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["1(6)"],"pubmed_abstract":["Extracellular vesicles (EVs), including exosomes and microvesicles, are far from being the only RNA-containing extracellular particles (EPs). Recently, new 35 nm-sized EPs were discovered by asymmetric-flow field-flow fractionation and termed \"exomeres\". Purification of exomeres was later performed by differential ultracentrifugation as well. More recently, the supernatant of the high-speed ultracentrifugation used to collect exomeres was further centrifuged to collect a new class of EP, termed \"supermeres\". Supermeres contain high quantities of extracellular RNA and are enriched in miR-1246. They are also replete in disease biomarkers and can induce metabolic and adaptive changes in recipient cells. Here, we reanalyzed proteomic and transcriptomic data obtained in this exciting study to o"],"journal":["Journal of extracellular biology"],"pubmed_title":["Exomeres and Supermeres: monolithic or diverse?"],"pmcid":["PMC9610496"],"funding_grant_id":["R01 AI144997","UH3 CA241694","R33 MH118164","UG3 CA241694","R01 DA047807"],"pubmed_authors":["Tosar JP","Cayota A","Witwer K"],"additional_accession":[]},"is_claimable":false,"name":"Exomeres and Supermeres: monolithic or diverse?","description":"Extracellular vesicles (EVs), including exosomes and microvesicles, are far from being the only RNA-containing extracellular particles (EPs). Recently, new 35 nm-sized EPs were discovered by asymmetric-flow field-flow fractionation and termed \"exomeres\". Purification of exomeres was later performed by differential ultracentrifugation as well. More recently, the supernatant of the high-speed ultracentrifugation used to collect exomeres was further centrifuged to collect a new class of EP, termed \"supermeres\". Supermeres contain high quantities of extracellular RNA and are enriched in miR-1246. They are also replete in disease biomarkers and can induce metabolic and adaptive changes in recipient cells. Here, we reanalyzed proteomic and transcriptomic data obtained in this exciting study to o","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-04-08T11:18:19.635Z","creation":"2024-11-19T23:15:24.439Z"},"accession":"S-EPMC9610496","cross_references":{"pubmed":["36311878"],"doi":["10.1002/jex2.45"]}}