biostudies-literatureTosar JPNIDA NIH HHSNIAID NIH HHSNIMH NIH HHSNCI NIH HHSe45https://www.ebi.ac.uk/biostudies/studies/S-EPMC9610496biostudies-literatureUnknown1(6)Extracellular vesicles (EVs), including exosomes and microvesicles, are far from being the only RNA-containing extracellular particles (EPs). Recently, new 35 nm-sized EPs were discovered by asymmetric-flow field-flow fractionation and termed "exomeres". Purification of exomeres was later performed by differential ultracentrifugation as well. More recently, the supernatant of the high-speed ultracentrifugation used to collect exomeres was further centrifuged to collect a new class of EP, termed "supermeres". Supermeres contain high quantities of extracellular RNA and are enriched in miR-1246. They are also replete in disease biomarkers and can induce metabolic and adaptive changes in recipient cells. Here, we reanalyzed proteomic and transcriptomic data obtained in this exciting study to oJournal of extracellular biologyExomeres and Supermeres: monolithic or diverse?PMC9610496R01 AI144997UH3 CA241694R33 MH118164UG3 CA241694R01 DA047807Tosar JPCayota AWitwer KfalseExomeres and Supermeres: monolithic or diverse?Extracellular vesicles (EVs), including exosomes and microvesicles, are far from being the only RNA-containing extracellular particles (EPs). Recently, new 35 nm-sized EPs were discovered by asymmetric-flow field-flow fractionation and termed "exomeres". Purification of exomeres was later performed by differential ultracentrifugation as well. More recently, the supernatant of the high-speed ultracentrifugation used to collect exomeres was further centrifuged to collect a new class of EP, termed "supermeres". Supermeres contain high quantities of extracellular RNA and are enriched in miR-1246. They are also replete in disease biomarkers and can induce metabolic and adaptive changes in recipient cells. Here, we reanalyzed proteomic and transcriptomic data obtained in this exciting study to o2022-01-01T00:00:00Z2022 Jun2026-04-08T11:18:19.635Z2024-11-19T23:15:24.439ZS-EPMC96104963631187810.1002/jex2.45