{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Santos AL"],"funding":["São Paulo Research Foundation","Fundação de Amparo à Pesquisa do Estado de São Paulo—FAPESP","Fundação de Amparo à Pesquisa do Estado de Minas Gerais FAPEMIG"],"pagination":["903"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9611219"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(10)"],"pubmed_abstract":["Endophytes have been shown to be a source of novel drug prototypes. The <i>Casearia</i> genus is known for presenting cytotoxic clerodane diterpenes; however, there are few reports on secondary metabolites produced by its fungal microbiota. Thus, in the present study endophytic fungi obtained from the fresh leaves of <i>C. arborea</i> were grown in potato dextrose broth and rice to perform a secondary metabolite prospection study. The cytotoxic profile of the crude extracts at 10 µg/mL was determined by a colorimetric assay on tumor cell lines. The endophytes producing cytotoxic extracts were identified through phylogenetic analysis and belong to <i>Diaporthe</i> and <i>Colletotrichum</i> species. Metabolites present in these extracts were organized in molecular networking format based on "],"journal":["Metabolites"],"pubmed_title":["Dereplication of Cytochalasans and Octaketides in Cytotoxic Extracts of Endophytic Fungi from <i>Casearia arborea</i> (Salicaceae)."],"pmcid":["PMC9611219"],"funding_grant_id":["2016/24985-4","2016/24985-4,","APQ 02036-21","APQ 00207-18","2020/16554-9"],"pubmed_authors":["Santos AL","Horvath RO","Soares MG","Ionta M","Ferreira MJP","Sartorelli P","Silva DO","Kawafune ES"],"additional_accession":[]},"is_claimable":false,"name":"Dereplication of Cytochalasans and Octaketides in Cytotoxic Extracts of Endophytic Fungi from <i>Casearia arborea</i> (Salicaceae).","description":"Endophytes have been shown to be a source of novel drug prototypes. The <i>Casearia</i> genus is known for presenting cytotoxic clerodane diterpenes; however, there are few reports on secondary metabolites produced by its fungal microbiota. Thus, in the present study endophytic fungi obtained from the fresh leaves of <i>C. arborea</i> were grown in potato dextrose broth and rice to perform a secondary metabolite prospection study. The cytotoxic profile of the crude extracts at 10 µg/mL was determined by a colorimetric assay on tumor cell lines. The endophytes producing cytotoxic extracts were identified through phylogenetic analysis and belong to <i>Diaporthe</i> and <i>Colletotrichum</i> species. Metabolites present in these extracts were organized in molecular networking format based on ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2026-04-08T18:22:09.074Z","creation":"2025-04-19T04:24:29.34Z"},"accession":"S-EPMC9611219","cross_references":{"pubmed":["36295805"],"doi":["10.3390/metabo12100903"]}}