{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tsai IA"],"funding":["Council of Agriculture, Executive Yuan of the Republic of China","Chiayi Chang Gung Memorial Hospital","Taiwan Agricultural Research Institute Council of Agriculture, Executive Yuan","Chang Gung Memorial Hospital, Chiayi, Taiwan"],"pagination":["1145"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9611264"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(10)"],"pubmed_abstract":["<i>Streptococcus agalactiae</i> (GBS) can infect newborns, pregnant women and immunocompromised or elderly people. This study aimed to investigate differences in three pilus genes and virulence genes <i>pavA</i>, <i>cfb</i>, <i>rib</i> and <i>scpB</i> and changes in predominant serotypes III, V and VI from 2008 to 2012. The susceptibilities to penicillin, ceftriaxone, azithromycin, erythromycin, clindamycin, levofloxacin and moxifloxacin of 145 GBS strains of serotype III, V and VI strains from 2008 and 2012 were determined using disc diffusion method. PCR identification of ST-17, the pilus genes and virulence genes; multilocus sequence typing (MLST); and conserved domain and phylogenetic analysis of <i>scpB-1</i> and <i>scpB-2</i> proteins were performed. A dramatic number reduction was o"],"journal":["Pathogens (Basel, Switzerland)"],"pubmed_title":["Alterations in Genes <i>rib</i>, <i>scpB</i> and Pilus Island Decrease the Prevalence of Predominant Serotype V, Not III and VI, of <i>Streptococcus agalactiae</i> from 2008 to 2012."],"pmcid":["PMC9611264"],"funding_grant_id":["108AS-8.6.1-BQ-B3","MRPG6K0272","109AS-8.6.1-BQ-B2","108AS-8.6.1-BQ-B3, and No. 109AS-8.6.1-BQ-B2"],"pubmed_authors":["Chu C","Su Y","Wang YH","Tsai IA"],"additional_accession":[]},"is_claimable":false,"name":"Alterations in Genes <i>rib</i>, <i>scpB</i> and Pilus Island Decrease the Prevalence of Predominant Serotype V, Not III and VI, of <i>Streptococcus agalactiae</i> from 2008 to 2012.","description":"<i>Streptococcus agalactiae</i> (GBS) can infect newborns, pregnant women and immunocompromised or elderly people. This study aimed to investigate differences in three pilus genes and virulence genes <i>pavA</i>, <i>cfb</i>, <i>rib</i> and <i>scpB</i> and changes in predominant serotypes III, V and VI from 2008 to 2012. The susceptibilities to penicillin, ceftriaxone, azithromycin, erythromycin, clindamycin, levofloxacin and moxifloxacin of 145 GBS strains of serotype III, V and VI strains from 2008 and 2012 were determined using disc diffusion method. PCR identification of ST-17, the pilus genes and virulence genes; multilocus sequence typing (MLST); and conserved domain and phylogenetic analysis of <i>scpB-1</i> and <i>scpB-2</i> proteins were performed. A dramatic number reduction was o","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-18T18:43:41.876Z","creation":"2024-10-18T20:32:50.732Z"},"accession":"S-EPMC9611264","cross_references":{"pubmed":["36297202"],"doi":["10.3390/pathogens11101145"]}}