biostudies-literatureTsai IACouncil of Agriculture, Executive Yuan of the Republic of ChinaChiayi Chang Gung Memorial HospitalTaiwan Agricultural Research Institute Council of Agriculture, Executive YuanChang Gung Memorial Hospital, Chiayi, Taiwan1145https://www.ebi.ac.uk/biostudies/studies/S-EPMC9611264biostudies-literatureUnknown11(10)<i>Streptococcus agalactiae</i> (GBS) can infect newborns, pregnant women and immunocompromised or elderly people. This study aimed to investigate differences in three pilus genes and virulence genes <i>pavA</i>, <i>cfb</i>, <i>rib</i> and <i>scpB</i> and changes in predominant serotypes III, V and VI from 2008 to 2012. The susceptibilities to penicillin, ceftriaxone, azithromycin, erythromycin, clindamycin, levofloxacin and moxifloxacin of 145 GBS strains of serotype III, V and VI strains from 2008 and 2012 were determined using disc diffusion method. PCR identification of ST-17, the pilus genes and virulence genes; multilocus sequence typing (MLST); and conserved domain and phylogenetic analysis of <i>scpB-1</i> and <i>scpB-2</i> proteins were performed. A dramatic number reduction was oPathogens (Basel, Switzerland)Alterations in Genes <i>rib</i>, <i>scpB</i> and Pilus Island Decrease the Prevalence of Predominant Serotype V, Not III and VI, of <i>Streptococcus agalactiae</i> from 2008 to 2012.PMC9611264108AS-8.6.1-BQ-B3MRPG6K0272109AS-8.6.1-BQ-B2108AS-8.6.1-BQ-B3, and No. 109AS-8.6.1-BQ-B2Chu CSu YWang YHTsai IAfalseAlterations in Genes <i>rib</i>, <i>scpB</i> and Pilus Island Decrease the Prevalence of Predominant Serotype V, Not III and VI, of <i>Streptococcus agalactiae</i> from 2008 to 2012.<i>Streptococcus agalactiae</i> (GBS) can infect newborns, pregnant women and immunocompromised or elderly people. This study aimed to investigate differences in three pilus genes and virulence genes <i>pavA</i>, <i>cfb</i>, <i>rib</i> and <i>scpB</i> and changes in predominant serotypes III, V and VI from 2008 to 2012. The susceptibilities to penicillin, ceftriaxone, azithromycin, erythromycin, clindamycin, levofloxacin and moxifloxacin of 145 GBS strains of serotype III, V and VI strains from 2008 and 2012 were determined using disc diffusion method. PCR identification of ST-17, the pilus genes and virulence genes; multilocus sequence typing (MLST); and conserved domain and phylogenetic analysis of <i>scpB-1</i> and <i>scpB-2</i> proteins were performed. A dramatic number reduction was o2022-01-01T00:00:00Z2022 Oct2025-04-18T18:43:41.876Z2024-10-18T20:32:50.732ZS-EPMC96112643629720210.3390/pathogens11101145