{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang S"],"funding":["Major International S&amp;T Cooperation Project, Ministry of Science and Technology of the People's Republic of China","Key Project of NMPA Key Laboratory for Quality Control of Traditional Chinese Medicine"],"pagination":["896"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9612088"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(10)"],"pubmed_abstract":["<i>Glycyrrhiza glabra</i> L., known as licorice, is one of the most famous herbs in the world. In this study, we investigated the phytochemical and antitumor activities of <i>G. glabra</i>, especially its anti-colorectal cancer activities. <i>G. glabra</i> was extracted with 70% methanol, and the ethyl acetate layer was separated by silica gel, ODS, LH-20 column chromatography, and semi-preparative HPLC to obtain the compounds. The structures were determined by NMR and MS methods. Three new compounds named licopyranol A-C (<b>1</b>-<b>3</b>), and eighteen known compounds (<b>4</b>-<b>21</b>) were isolated. Compounds with an isoprenyl group or dimethylpyran ring showed better antitumor activities. Licopyranol A (<b>1</b>) and glycyrol (<b>5</b>) both inhibited the proliferation, reduced clo"],"journal":["Metabolites"],"pubmed_title":["Three New Compounds, Licopyranol A-C, Together with Eighteen Known Compounds Isolated from <i>Glycyrrhiza glabra</i> L. and Their Antitumor Activities."],"pmcid":["PMC9612088"],"funding_grant_id":["2020GSMPA-KL11","2016YFE0129000"],"pubmed_authors":["Jiang Y","Liu Y","Chen Q","Li Y","Yang Z","He D","Bi C","Wang S","Shen X","Alafifi JH","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"Three New Compounds, Licopyranol A-C, Together with Eighteen Known Compounds Isolated from <i>Glycyrrhiza glabra</i> L. and Their Antitumor Activities.","description":"<i>Glycyrrhiza glabra</i> L., known as licorice, is one of the most famous herbs in the world. In this study, we investigated the phytochemical and antitumor activities of <i>G. glabra</i>, especially its anti-colorectal cancer activities. <i>G. glabra</i> was extracted with 70% methanol, and the ethyl acetate layer was separated by silica gel, ODS, LH-20 column chromatography, and semi-preparative HPLC to obtain the compounds. The structures were determined by NMR and MS methods. Three new compounds named licopyranol A-C (<b>1</b>-<b>3</b>), and eighteen known compounds (<b>4</b>-<b>21</b>) were isolated. Compounds with an isoprenyl group or dimethylpyran ring showed better antitumor activities. Licopyranol A (<b>1</b>) and glycyrol (<b>5</b>) both inhibited the proliferation, reduced clo","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-05-29T14:37:18.741Z","creation":"2024-10-19T01:42:43.448Z"},"accession":"S-EPMC9612088","cross_references":{"pubmed":["36295798"],"doi":["10.3390/metabo12100896"]}}