{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shen S"],"funding":["ODNI | Intelligence Advanced Research Projects Activity","NEI NIH HHS","U.S. Department of Health & Human Services | NIH | National Eye Institute","NIMH NIH HHS","NINDS NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute of Mental Health"],"pagination":["6389"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9613627"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Neocortical feedback is critical for attention, prediction, and learning. To mechanically understand its function requires deciphering its cell-type wiring. Recent studies revealed that feedback between primary motor to primary somatosensory areas in mice is disinhibitory, targeting vasoactive intestinal peptide-expressing interneurons, in addition to pyramidal cells. It is unknown whether this circuit motif represents a general cortico-cortical feedback organizing principle. Here we show that in contrast to this wiring rule, feedback between higher-order lateromedial visual area to primary visual cortex preferentially activates somatostatin-expressing interneurons. Functionally, both feedback circuits temporally sharpen feed-forward excitation eliciting a transient increase-followed by a prolonged decrease-in pyramidal cell activity under sustained feed-forward input. However, under feed-forward transient input, the primary motor to primary somatosensory cortex feedback facilitates bursting while lateromedial area to primary visual cortex feedback increases time precision. Our findings argue for multiple cortico-cortical feedback motifs implementing different dynamic non-linear operations."],"journal":["Nature communications"],"pubmed_title":["Distinct organization of two cortico-cortical feedback pathways."],"pmcid":["PMC9613627"],"funding_grant_id":["R01 EY033492","R01 MH120404","R01 NS110767","R01 MH109556","D16PC00003","P30EY002520","R01 MH122169","P30 EY002520","R01EY026927"],"pubmed_authors":["Scala F","Fahey P","Kobak D","Zhou N","Sinz F","Tan Z","Jiang X","Fu J","Tolias AS","Shen S","Reimer J"],"additional_accession":[]},"is_claimable":false,"name":"Distinct organization of two cortico-cortical feedback pathways.","description":"Neocortical feedback is critical for attention, prediction, and learning. To mechanically understand its function requires deciphering its cell-type wiring. Recent studies revealed that feedback between primary motor to primary somatosensory areas in mice is disinhibitory, targeting vasoactive intestinal peptide-expressing interneurons, in addition to pyramidal cells. It is unknown whether this circuit motif represents a general cortico-cortical feedback organizing principle. Here we show that in contrast to this wiring rule, feedback between higher-order lateromedial visual area to primary visual cortex preferentially activates somatostatin-expressing interneurons. Functionally, both feedback circuits temporally sharpen feed-forward excitation eliciting a transient increase-followed by a prolonged decrease-in pyramidal cell activity under sustained feed-forward input. However, under feed-forward transient input, the primary motor to primary somatosensory cortex feedback facilitates bursting while lateromedial area to primary visual cortex feedback increases time precision. Our findings argue for multiple cortico-cortical feedback motifs implementing different dynamic non-linear operations.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-06-01T04:06:57.824Z","creation":"2025-06-01T04:06:57.824Z"},"accession":"S-EPMC9613627","cross_references":{"pubmed":["36302912"],"doi":["10.1038/s41467-022-33883-9"]}}