{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(10)"],"submitter":["Guo WH"],"pubmed_abstract":["Islet β cell dysfunction and insulin resistance are the main pathogenesis of type 2 diabetes (T2D), but the mechanism remains unclear. Here we identify a rs3819316 C > T mutation in lncRNA Reg1cp mainly expressed in islets associated with an increased risk of T2D. Analyses in 16,113 Chinese adults reveal that Mut-Reg1cp individuals had higher incidence of T2D and presented impaired insulin secretion as well as increased insulin resistance. Mice with islet β cell specific Mut-Reg1cp knock-in have more severe β cell dysfunction and insulin resistance. Mass spectrometry assay of proteins after RNA pulldown demonstrate that Mut-Reg1cp directly binds to polypyrimidine tract binding protein 1 (PTBP1), further immunofluorescence staining, western blot analysis, qPCR analysis and glucose stimulate"],"journal":["Cell death & disease"],"pagination":["904"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9613878"],"repository":["biostudies-literature"],"pubmed_title":["Mutated lncRNA increase the risk of type 2 diabetes by promoting β cell dysfunction and insulin resistance."],"pmcid":["PMC9613878"],"pubmed_authors":["Yan DD","Yan J","Liu YL","Yang M","Guo WH","Guo Q","Zhang R","Luo XH","Jin L"],"additional_accession":[]},"is_claimable":false,"name":"Mutated lncRNA increase the risk of type 2 diabetes by promoting β cell dysfunction and insulin resistance.","description":"Islet β cell dysfunction and insulin resistance are the main pathogenesis of type 2 diabetes (T2D), but the mechanism remains unclear. Here we identify a rs3819316 C > T mutation in lncRNA Reg1cp mainly expressed in islets associated with an increased risk of T2D. Analyses in 16,113 Chinese adults reveal that Mut-Reg1cp individuals had higher incidence of T2D and presented impaired insulin secretion as well as increased insulin resistance. Mice with islet β cell specific Mut-Reg1cp knock-in have more severe β cell dysfunction and insulin resistance. Mass spectrometry assay of proteins after RNA pulldown demonstrate that Mut-Reg1cp directly binds to polypyrimidine tract binding protein 1 (PTBP1), further immunofluorescence staining, western blot analysis, qPCR analysis and glucose stimulate","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-06-01T02:15:58.505Z","creation":"2025-02-19T01:29:05.712Z"},"accession":"S-EPMC9613878","cross_references":{"pubmed":["36302749"],"doi":["10.1038/s41419-022-05348-w"]}}