biostudies-literatureUnknown9Worku G<h4>Background</h4>Tuberculosis (TB) is one of the leading causes of morbidity and mortality in low-income countries like Ethiopia. However, because of the limited laboratory infrastructure there is a shortage of comprehensive data on the genotypes of clinical isolates of <i>Mycobacterium tuberculosis</i> (<i>M. tuberculosis</i>) complex (MTBC) in peripheral regions of Ethiopia. The objective of this study was to characterize MTBC isolates in the Somali region of eastern Ethiopia.<h4>Methods</h4>A cross-sectional study was conducted in three health institutions between October 2018 and December 2019 in the capital of Somali region. A total of 323 MTBC isolates (249 from pulmonary TB and 74 from extrapulmonary TB) were analyzed using regions of difference 9 (RD 9)-based polymerase chain reaFrontiers in medicine960590https://www.ebi.ac.uk/biostudies/studies/S-EPMC9614095biostudies-literatureMolecular epidemiology of tuberculosis in the Somali region, eastern Ethiopia.PMC9614095Ashagre WTschopp RGirma MAmeni GWondimu ASileshi HGumi BHailu MCarruth LWorku GMohammedbirhan BfalseMolecular epidemiology of tuberculosis in the Somali region, eastern Ethiopia.<h4>Background</h4>Tuberculosis (TB) is one of the leading causes of morbidity and mortality in low-income countries like Ethiopia. However, because of the limited laboratory infrastructure there is a shortage of comprehensive data on the genotypes of clinical isolates of <i>Mycobacterium tuberculosis</i> (<i>M. tuberculosis</i>) complex (MTBC) in peripheral regions of Ethiopia. The objective of this study was to characterize MTBC isolates in the Somali region of eastern Ethiopia.<h4>Methods</h4>A cross-sectional study was conducted in three health institutions between October 2018 and December 2019 in the capital of Somali region. A total of 323 MTBC isolates (249 from pulmonary TB and 74 from extrapulmonary TB) were analyzed using regions of difference 9 (RD 9)-based polymerase chain rea2022-01-01T00:00:00Z20222025-04-04T09:41:54.706Z2025-04-04T09:41:54.706ZS-EPMC96140953631399910.3389/fmed.2022.960590