{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Morfill C"],"funding":["Cancer Research UK","FP7 People: Marie-Curie Actions","Medical Research Council","Imperial College London","Royal Society of Chemistry","Wellcome Trust","Division of Intramural Research, National Institute of Allergy and Infectious Diseases","Engineering and Physical Sciences Research Council","Michael J. Fox Foundation for Parkinson's Research"],"pagination":["47445-47460"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9614720"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(42)"],"pubmed_abstract":["A challenge in neurology is the lack of efficient brain-penetrable neuroprotectants targeting multiple disease mechanisms. Plasmonic gold nanostars are promising candidates to deliver standard-of-care drugs inside the brain but have not been trialed as carriers for neuroprotectants. Here, we conjugated custom-made peptide dendrimers (termed H3/H6), encompassing motifs of the neurotrophic S100A4-protein, onto star-shaped and spherical gold nanostructures (H3/H6-AuNS/AuNP) and evaluated their potential as neuroprotectants and interaction with neurons. The H3/H6 nanostructures crossed a model blood-brain barrier, bound to plasma membranes, and induced neuritogenesis with the AuNS, showing higher potency/efficacy than the AuNP. The H3-AuNS/NP protected neurons against oxidative stress, the H3-"],"journal":["ACS applied materials & interfaces"],"pubmed_title":["Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative Disorders."],"pmcid":["PMC9614720"],"funding_grant_id":["11713","EP/L015277/1","R01AI145436","P627049","FC0010218"],"pubmed_authors":["Kiryushko D","Fernando NK","Pinna A","Pankratova S","Klosowski M","Wilkinson RJ","Machado P","Talamona F","Morfill C","Xie F","Regoutz A","Porter AE","Fleck RA"],"additional_accession":[]},"is_claimable":false,"name":"Nanostars Carrying Multifunctional Neurotrophic Dendrimers Protect Neurons in Preclinical In Vitro Models of Neurodegenerative Disorders.","description":"A challenge in neurology is the lack of efficient brain-penetrable neuroprotectants targeting multiple disease mechanisms. Plasmonic gold nanostars are promising candidates to deliver standard-of-care drugs inside the brain but have not been trialed as carriers for neuroprotectants. Here, we conjugated custom-made peptide dendrimers (termed H3/H6), encompassing motifs of the neurotrophic S100A4-protein, onto star-shaped and spherical gold nanostructures (H3/H6-AuNS/AuNP) and evaluated their potential as neuroprotectants and interaction with neurons. The H3/H6 nanostructures crossed a model blood-brain barrier, bound to plasma membranes, and induced neuritogenesis with the AuNS, showing higher potency/efficacy than the AuNP. The H3-AuNS/NP protected neurons against oxidative stress, the H3-","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T09:42:22.966Z","creation":"2025-04-04T09:42:22.966Z"},"accession":"S-EPMC9614720","cross_references":{"pubmed":["36218307"],"doi":["10.1021/acsami.2c14220"]}}