biostudies-literatureMiao ZH2020 Marie Sklodowska-Curie ActionsUniversity of Southern CaliforniaDivision of Materials Research8331-8338https://www.ebi.ac.uk/biostudies/studies/S-EPMC9614958biostudies-literatureUnknown22(20)Relationships between chemical structure and conductivity in ordered polymers (OPs) are difficult to probe using bulk samples. We propose that conductance measurements of appropriate molecular-scale models can reveal trends in electronic coupling(s) between repeat units that may help inform OP design. Here, we apply the scanning tunneling microscope-based break-junction (STM-BJ) method to study transport through single-molecules comprising OP-relevant imine, imidazole, diazaborole, and boronate ester dynamic covalent chemical bridges. Notably, solution-stable boron-based compounds dissociate <i>in situ</i> unless measured under a rigorously inert glovebox atmosphere. We find that junction conductance negatively correlates with the electronegativity difference between bridge atoms, and corrNano lettersCharge Transport Across Dynamic Covalent Chemical Bridges.PMC9614958DMR-2044552898657Parr JMInkpen MSCzyszczon-Burton TMRotthowe NLiu ZFQuainoo TMiao ZfalseCharge Transport Across Dynamic Covalent Chemical Bridges.Relationships between chemical structure and conductivity in ordered polymers (OPs) are difficult to probe using bulk samples. We propose that conductance measurements of appropriate molecular-scale models can reveal trends in electronic coupling(s) between repeat units that may help inform OP design. Here, we apply the scanning tunneling microscope-based break-junction (STM-BJ) method to study transport through single-molecules comprising OP-relevant imine, imidazole, diazaborole, and boronate ester dynamic covalent chemical bridges. Notably, solution-stable boron-based compounds dissociate <i>in situ</i> unless measured under a rigorously inert glovebox atmosphere. We find that junction conductance negatively correlates with the electronegativity difference between bridge atoms, and corr2022-01-01T00:00:00Z2022 Oct2025-04-04T09:42:07.613Z2025-04-04T09:42:07.613ZS-EPMC96149583621524610.1021/acs.nanolett.2c03288