{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["20(1)"],"submitter":["Wu Z"],"funding":["Universitätsklinik München"],"pubmed_abstract":["The M2-like tumor-associated macrophages (TAMs) are independent prognostic factors in melanoma. We performed weighted gene co-expression network analysis (WGCNA) to identify the module most correlated with M2-like TAMs. The Cancer Genome Atlas (TCGA) patients were classified into two clusters that differed based on prognosis and biological function, with consensus clustering. A prognostic model was established based on the differentially expressed genes (DEGs) of the two clusters. We investigated the difference in immune cell infiltration and immune response-related gene expression between the high and low risk score groups. The risk score was defined as an independent prognostic value in melanoma. VARS1 was a hub gene in the M2-like macrophage-associated WGCNA module that the DepMap porta"],"journal":["Journal of translational medicine"],"pagination":["489"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9615154"],"repository":["biostudies-literature"],"pubmed_title":["Transcriptome-based network analysis related to M2-like tumor-associated macrophage infiltration identified VARS1 as a potential target for improving melanoma immunotherapy efficacy."],"pmcid":["PMC9615154"],"pubmed_authors":["Wu Z","Li H","Lei K","He J","Shi E"],"additional_accession":[]},"is_claimable":false,"name":"Transcriptome-based network analysis related to M2-like tumor-associated macrophage infiltration identified VARS1 as a potential target for improving melanoma immunotherapy efficacy.","description":"The M2-like tumor-associated macrophages (TAMs) are independent prognostic factors in melanoma. We performed weighted gene co-expression network analysis (WGCNA) to identify the module most correlated with M2-like TAMs. The Cancer Genome Atlas (TCGA) patients were classified into two clusters that differed based on prognosis and biological function, with consensus clustering. A prognostic model was established based on the differentially expressed genes (DEGs) of the two clusters. We investigated the difference in immune cell infiltration and immune response-related gene expression between the high and low risk score groups. The risk score was defined as an independent prognostic value in melanoma. VARS1 was a hub gene in the M2-like macrophage-associated WGCNA module that the DepMap porta","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-05-31T22:35:35.457Z","creation":"2024-11-10T02:42:34.791Z"},"accession":"S-EPMC9615154","cross_references":{"pubmed":["36303162"],"doi":["10.1186/s12967-022-03686-z"]}}