{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hill JC"],"funding":["NHLBI NIH HHS","National Institutes of Health"],"pagination":["ezac237"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9615433"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["62(5)"],"pubmed_abstract":["<h4>Objectives</h4>We hypothesized that expression and activity of nitric oxide synthase-3 enzyme (Nos3) in bicuspid aortic valve (BAV) aortopathy are related to tissue layer and Nos3 genotype.<h4>Methods</h4>Gene expression of Nos3 and platelet and endothelial cell adhesion molecule-1 (Pecam1) and NOS activity were measured in intima-containing media and adventitial specimens of ascending aortic tissue. The presence of 2 Nos3 single-nucleotide polymorphisms (SNPs; -786T/C and 894G/T) was determined for non-aneurysmal (NA) and aneurysmal patients with BAV (n = 40, 89, respectively); patients with tricuspid aortic valve (TAV) and aneurysm (n = 151); and NA patients with TAV (n = 100).<h4>Results</h4>Elevated Nos3 relative to Pecam1 and reduced Pecam1 relative to a housekeeping gene were obs"],"journal":["European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery"],"pubmed_title":["Layer-specific Nos3 expression and genotypic distribution in bicuspid aortic valve aortopathy."],"pmcid":["PMC9615433"],"funding_grant_id":["HL109132","R01 HL131632","R01 HL109132","HL131632"],"pubmed_authors":["Kotlarczyk MP","Phillippi JA","Richards TD","Hill JC","Shiva S","Gleason TG","Billaud M"],"additional_accession":[]},"is_claimable":false,"name":"Layer-specific Nos3 expression and genotypic distribution in bicuspid aortic valve aortopathy.","description":"<h4>Objectives</h4>We hypothesized that expression and activity of nitric oxide synthase-3 enzyme (Nos3) in bicuspid aortic valve (BAV) aortopathy are related to tissue layer and Nos3 genotype.<h4>Methods</h4>Gene expression of Nos3 and platelet and endothelial cell adhesion molecule-1 (Pecam1) and NOS activity were measured in intima-containing media and adventitial specimens of ascending aortic tissue. The presence of 2 Nos3 single-nucleotide polymorphisms (SNPs; -786T/C and 894G/T) was determined for non-aneurysmal (NA) and aneurysmal patients with BAV (n = 40, 89, respectively); patients with tricuspid aortic valve (TAV) and aneurysm (n = 151); and NA patients with TAV (n = 100).<h4>Results</h4>Elevated Nos3 relative to Pecam1 and reduced Pecam1 relative to a housekeeping gene were obs","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-04-08T12:08:53.065Z","creation":"2025-02-19T04:15:52.464Z"},"accession":"S-EPMC9615433","cross_references":{"pubmed":["35460403"],"doi":["10.1093/ejcts/ezac237"]}}