{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang ZJ"],"funding":["NIDA NIH HHS","NIMH NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse","U.S. Department of Health & Human Services | National Institutes of Health"],"pagination":["3056-3068"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9615910"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["27(7)"],"pubmed_abstract":["Chronic social isolation stress during adolescence induces susceptibility for neuropsychiatric disorders. Here we show that 5-week post-weaning isolation stress induces sex-specific behavioral abnormalities and neuronal activity changes in the prefrontal cortex (PFC), basal lateral amygdala (BLA), and ventral tegmental area (VTA). Chemogenetic manipulation, optogenetic recording, and in vivo calcium imaging identify that the PFC to BLA pathway is causally linked to heightened aggression in stressed males, and the PFC to VTA pathway is causally linked to social withdrawal in stressed females. Isolation stress induces genome-wide transcriptional alterations in a region-specific manner. Particularly, the upregulated genes in BLA of stressed males are under the control of activated transcripti"],"journal":["Molecular psychiatry"],"pubmed_title":["Molecular and cellular mechanisms for differential effects of chronic social isolation stress in males and females."],"pmcid":["PMC9615910"],"funding_grant_id":["R01 MH126443","R01 MH108842","MH126443","DA050908","R01 MH111872","MH111872","K01 DA050908"],"pubmed_authors":["Zhang F","Liu J","Zhong P","Yan Z","Schatz K","Pralle A","Shwani T","Wang ZJ","Yang F"],"additional_accession":[]},"is_claimable":false,"name":"Molecular and cellular mechanisms for differential effects of chronic social isolation stress in males and females.","description":"Chronic social isolation stress during adolescence induces susceptibility for neuropsychiatric disorders. Here we show that 5-week post-weaning isolation stress induces sex-specific behavioral abnormalities and neuronal activity changes in the prefrontal cortex (PFC), basal lateral amygdala (BLA), and ventral tegmental area (VTA). Chemogenetic manipulation, optogenetic recording, and in vivo calcium imaging identify that the PFC to BLA pathway is causally linked to heightened aggression in stressed males, and the PFC to VTA pathway is causally linked to social withdrawal in stressed females. Isolation stress induces genome-wide transcriptional alterations in a region-specific manner. Particularly, the upregulated genes in BLA of stressed males are under the control of activated transcripti","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2025-04-04T09:42:03.132Z","creation":"2025-04-04T09:42:03.132Z"},"accession":"S-EPMC9615910","cross_references":{"pubmed":["35449296"],"doi":["10.1038/s41380-022-01574-y"]}}