{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Novak B"],"funding":["Biotechnology and Biological Sciences Research Council"],"pagination":["2780-2785.e2"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9616797"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["32(12)"],"pubmed_abstract":["In 1996, Kim Nasmyth<sup>1</sup> proposed that the eukaryotic cell cycle is an alternating sequence of transitions from G<sub>1</sub> to S-G<sub>2</sub>-M and back again. These two phases correlate to high activity of cyclin-dependent kinases (CDKs) that trigger S-G<sub>2</sub>-M events and CDK antagonists that stabilize G<sub>1</sub> phase. We associated these \"alternative phases\" with the coexistence of two stable steady states of the biochemical reactions among CDKs and their antagonists.<sup>2</sup><sup>,</sup><sup>3</sup> Transitions between these steady states (G<sub>1</sub>-to-S and M-to-G<sub>1</sub>) are driven by \"helper\" proteins. The fact that the transitions are irreversible is guaranteed by a \"latching\" property of the molecular switches, as we have argued in previous publica"],"journal":["Current biology : CB"],"pubmed_title":["Mitotic kinase oscillation governs the latching of cell cycle switches."],"pmcid":["PMC9616797"],"funding_grant_id":["BB/M00354X/1"],"pubmed_authors":["Tyson JJ","Novak B"],"additional_accession":[]},"is_claimable":false,"name":"Mitotic kinase oscillation governs the latching of cell cycle switches.","description":"In 1996, Kim Nasmyth<sup>1</sup> proposed that the eukaryotic cell cycle is an alternating sequence of transitions from G<sub>1</sub> to S-G<sub>2</sub>-M and back again. These two phases correlate to high activity of cyclin-dependent kinases (CDKs) that trigger S-G<sub>2</sub>-M events and CDK antagonists that stabilize G<sub>1</sub> phase. We associated these \"alternative phases\" with the coexistence of two stable steady states of the biochemical reactions among CDKs and their antagonists.<sup>2</sup><sup>,</sup><sup>3</sup> Transitions between these steady states (G<sub>1</sub>-to-S and M-to-G<sub>1</sub>) are driven by \"helper\" proteins. The fact that the transitions are irreversible is guaranteed by a \"latching\" property of the molecular switches, as we have argued in previous publica","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2025-04-19T04:20:19.932Z","creation":"2025-04-19T04:20:19.932Z"},"accession":"S-EPMC9616797","cross_references":{"pubmed":["35504285"],"doi":["10.1016/j.cub.2022.04.016"]}}