{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["42(11)"],"submitter":["Meng X"],"funding":["IMPACT Therapeutics"],"pubmed_abstract":["<h4>Background and objectives</h4>Data on the effect of food on the pharmacokinetics of senaparib (previously IMP4297), an oral poly (adenosine diphosphate-ribose) polymerase inhibitor, are limited. This study was conducted to evaluate the effect of food on the pharmacokinetics of senaparib in healthy Chinese subjects.<h4>Methods</h4>This is a phase I, open-label, randomized, single-dose, two-way crossover study. Healthy Chinese male subjects were randomized 1:1 to receive a single dose of senaparib 100 mg in two prandial states: fasted or after a high-fat meal; subjects were given a second dose after switching prandial states and a washout period of at least 7 days. Pharmacokinetics were assessed at pre-dose and up to 72 h post-dose. Safety was assessed throughout the study.<h4>Results</h"],"journal":["Clinical drug investigation"],"pagination":["1009-1016"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9617823"],"repository":["biostudies-literature"],"pubmed_title":["Effect of Food on the Pharmacokinetics of Senaparib (IMP4297) in Healthy Chinese Subjects."],"pmcid":["PMC9617823"],"pubmed_authors":["Cao M","Zhang J","Lu Y","Zeng L","Lin X","Jiang R","Meng X"],"additional_accession":[]},"is_claimable":false,"name":"Effect of Food on the Pharmacokinetics of Senaparib (IMP4297) in Healthy Chinese Subjects.","description":"<h4>Background and objectives</h4>Data on the effect of food on the pharmacokinetics of senaparib (previously IMP4297), an oral poly (adenosine diphosphate-ribose) polymerase inhibitor, are limited. This study was conducted to evaluate the effect of food on the pharmacokinetics of senaparib in healthy Chinese subjects.<h4>Methods</h4>This is a phase I, open-label, randomized, single-dose, two-way crossover study. Healthy Chinese male subjects were randomized 1:1 to receive a single dose of senaparib 100 mg in two prandial states: fasted or after a high-fat meal; subjects were given a second dose after switching prandial states and a washout period of at least 7 days. Pharmacokinetics were assessed at pre-dose and up to 72 h post-dose. Safety was assessed throughout the study.<h4>Results</h","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-04T13:31:52.931Z","creation":"2025-02-19T04:03:05.994Z"},"accession":"S-EPMC9617823","cross_references":{"pubmed":["36239914"],"doi":["10.1007/s40261-022-01198-8"]}}