biostudies-literatureUnknown42(11)Meng XIMPACT Therapeutics<h4>Background and objectives</h4>Data on the effect of food on the pharmacokinetics of senaparib (previously IMP4297), an oral poly (adenosine diphosphate-ribose) polymerase inhibitor, are limited. This study was conducted to evaluate the effect of food on the pharmacokinetics of senaparib in healthy Chinese subjects.<h4>Methods</h4>This is a phase I, open-label, randomized, single-dose, two-way crossover study. Healthy Chinese male subjects were randomized 1:1 to receive a single dose of senaparib 100 mg in two prandial states: fasted or after a high-fat meal; subjects were given a second dose after switching prandial states and a washout period of at least 7 days. Pharmacokinetics were assessed at pre-dose and up to 72 h post-dose. Safety was assessed throughout the study.<h4>Results</hClinical drug investigation1009-1016https://www.ebi.ac.uk/biostudies/studies/S-EPMC9617823biostudies-literatureEffect of Food on the Pharmacokinetics of Senaparib (IMP4297) in Healthy Chinese Subjects.PMC9617823Cao MZhang JLu YZeng LLin XJiang RMeng XfalseEffect of Food on the Pharmacokinetics of Senaparib (IMP4297) in Healthy Chinese Subjects.<h4>Background and objectives</h4>Data on the effect of food on the pharmacokinetics of senaparib (previously IMP4297), an oral poly (adenosine diphosphate-ribose) polymerase inhibitor, are limited. This study was conducted to evaluate the effect of food on the pharmacokinetics of senaparib in healthy Chinese subjects.<h4>Methods</h4>This is a phase I, open-label, randomized, single-dose, two-way crossover study. Healthy Chinese male subjects were randomized 1:1 to receive a single dose of senaparib 100 mg in two prandial states: fasted or after a high-fat meal; subjects were given a second dose after switching prandial states and a washout period of at least 7 days. Pharmacokinetics were assessed at pre-dose and up to 72 h post-dose. Safety was assessed throughout the study.<h4>Results</h2022-01-01T00:00:00Z2022 Nov2025-04-04T13:31:52.931Z2025-02-19T04:03:05.994ZS-EPMC96178233623991410.1007/s40261-022-01198-8