{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jarjour NN"],"funding":["HHS | NIH | National Cancer Institute","NIAID NIH HHS","HHS | NIH | National Institute of Allergy and Infectious Diseases","NCI NIH HHS","Damon Runyon Cancer Research Foundation"],"pagination":["e2209021119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9618124"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["119(43)"],"pubmed_abstract":["Interleukin-15 (IL-15) is often considered a central regulator of memory CD8<sup>+</sup> T cells, based primarily on studies of recirculating subsets. However, recent work identified IL-15-independent CD8<sup>+</sup> T cell memory populations, including tissue-resident memory CD8<sup>+</sup> T cells (T<sub>RM</sub>) in some nonlymphoid tissues (NLTs). Whether this reflects the existence of IL-15-insensitive memory CD8<sup>+</sup> T cells is unclear. We report that IL-15 complexes (IL-15c) stimulate rapid proliferation and expansion of both tissue-resident and circulating memory CD8<sup>+</sup> T cell subsets across lymphoid and nonlymphoid tissues with varying magnitude by tissue and memory subset, in some sites correlating with differing levels of the IL-2Rβ. This was conserved for memory"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Responsiveness to interleukin-15 therapy is shared between tissue-resident and circulating memory CD8<sup>+</sup> T cell subsets."],"pmcid":["PMC9618124"],"funding_grant_id":["AI139381","R29 AI038903","R37 AI038903","K99 AI139381","AI038903","F99 CA245735","F30 CA250321","CA245735","DRG-2427-21","K00 CA245735","F30 CA253992","CA250321","R01 AI038903","CA253992","R00 AI139381"],"pubmed_authors":["Hamilton SE","Jarjour NN","Maurice NJ","Dalzell TS","Martinez RJ","Peng C","Jameson SC","Borges da Silva H","Huggins MA","Gavil NV","Wanhainen KM","Masopust D"],"additional_accession":[]},"is_claimable":false,"name":"Responsiveness to interleukin-15 therapy is shared between tissue-resident and circulating memory CD8<sup>+</sup> T cell subsets.","description":"Interleukin-15 (IL-15) is often considered a central regulator of memory CD8<sup>+</sup> T cells, based primarily on studies of recirculating subsets. However, recent work identified IL-15-independent CD8<sup>+</sup> T cell memory populations, including tissue-resident memory CD8<sup>+</sup> T cells (T<sub>RM</sub>) in some nonlymphoid tissues (NLTs). Whether this reflects the existence of IL-15-insensitive memory CD8<sup>+</sup> T cells is unclear. We report that IL-15 complexes (IL-15c) stimulate rapid proliferation and expansion of both tissue-resident and circulating memory CD8<sup>+</sup> T cell subsets across lymphoid and nonlymphoid tissues with varying magnitude by tissue and memory subset, in some sites correlating with differing levels of the IL-2Rβ. This was conserved for memory","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-03-31T11:52:58.165Z","creation":"2025-04-04T22:59:06.688Z"},"accession":"S-EPMC9618124","cross_references":{"pubmed":["36260745"],"doi":["10.1073/pnas.2209021119"]}}