biostudies-literatureZhang WFoundation of Shanghai Municipal Health CommissionFoundation of ChongmingClinical Research Plan of Shanghai Tenth People’s HospitalFundamental Research Funds for Central UniversitiesChinese National Natural Science FoundationClinical Research Plan of SHDCShanghai Natural Science Foundation of China222https://www.ebi.ac.uk/biostudies/studies/S-EPMC9618191biostudies-literatureUnknown21(1)<h4>Background</h4>Coronary microvascular dysfunction (CMD) is common and is associated with unfavorable cardiovascular events in patients with diabetes mellitus (DM). Coronary angiography-derived index of microcirculatory resistance (caIMR) is a recently developed wire- and hyperemic agent-free method to assess CMD. We aimed to investigate the prognostic impact of CMD assessed by caIMR on clinical outcomes in patients with DM and chronic coronary syndrome (CCS).<h4>Methods</h4>CCS patients who underwent coronary angiography between June 2015 to May 2018 were included. Coronary microvascular function was measured by caIMR, and CMD was defined as caIMR ≥ 25U. The primary endpoint was major adverse cardiac events (MACE). Kaplan-Meier analysis and Cox proportional hazards models were used to Cardiovascular diabetologyPrognostic value of coronary microvascular dysfunction assessed by coronary angiography-derived index of microcirculatory resistance in diabetic patients with chronic coronary syndrome.PMC96181912212019021182170521CKY2021-21, CKY2020-29202140263SHDC2020CR4065YNCR2A00121ZR1449500Mareai RMMohammed AALiu LLv XJiang RShi TFeng CAbdu FAZhang WYin GMohammed AQChe WXu SSingh SYu XXu YfalsePrognostic value of coronary microvascular dysfunction assessed by coronary angiography-derived index of microcirculatory resistance in diabetic patients with chronic coronary syndrome.<h4>Background</h4>Coronary microvascular dysfunction (CMD) is common and is associated with unfavorable cardiovascular events in patients with diabetes mellitus (DM). Coronary angiography-derived index of microcirculatory resistance (caIMR) is a recently developed wire- and hyperemic agent-free method to assess CMD. We aimed to investigate the prognostic impact of CMD assessed by caIMR on clinical outcomes in patients with DM and chronic coronary syndrome (CCS).<h4>Methods</h4>CCS patients who underwent coronary angiography between June 2015 to May 2018 were included. Coronary microvascular function was measured by caIMR, and CMD was defined as caIMR ≥ 25U. The primary endpoint was major adverse cardiac events (MACE). Kaplan-Meier analysis and Cox proportional hazards models were used to 2022-01-01T00:00:00Z2022 Oct2025-04-18T16:56:02.227Z2025-04-07T04:22:17.956ZS-EPMC96181913630972410.1186/s12933-022-01653-y