biostudies-literatureUnknown90Ma XYeast β-glucan (YG) possess an extensive range of biological activities, such as the inhibition of oxidation, but the poor water solubility of macromolecular YG limits its application. In this study, through the combined degradation of ultrasonic waves and H₂O₂, and the optimization of the main process parameters for solubilizing YG by response surface methodology (RSM), a new product of YG_UH was generated. The molecular weight, structural characteristics and degradation kinetics before and after solubilization were evaluated. The results showed that the optimal solubilization conditions were reaction time: 4 h, ultrasonic power: 3 W/mL, H₂O₂ concentration: 24 %. Under these conditions, ultrasound-assisted H₂O₂ inUltrasonics sonochemistry106210https://www.ebi.ac.uk/biostudies/studies/S-EPMC9619374biostudies-literatureEffects of ultrasound-assisted H₂O₂ on the solubilization and antioxidant activity of yeast β-glucan.PMC9619374He YMa XDong LChen SfalseEffects of ultrasound-assisted H₂O₂ on the solubilization and antioxidant activity of yeast β-glucan.Yeast β-glucan (YG) possess an extensive range of biological activities, such as the inhibition of oxidation, but the poor water solubility of macromolecular YG limits its application. In this study, through the combined degradation of ultrasonic waves and H₂O₂, and the optimization of the main process parameters for solubilizing YG by response surface methodology (RSM), a new product of YG_UH was generated. The molecular weight, structural characteristics and degradation kinetics before and after solubilization were evaluated. The results showed that the optimal solubilization conditions were reaction time: 4 h, ultrasonic power: 3 W/mL, H₂O₂ concentration: 24 %. Under these conditions, ultrasound-assisted H₂O₂ in2022-01-01T00:00:00Z2022 Oct2025-04-05T13:27:33.875Z2025-04-05T13:27:33.875ZS-EPMC96193743632792210.1016/j.ultsonch.2022.106210