{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Keil JM"],"funding":["Cleveland State University","National Institute of General Medical Sciences","NIGMS NIH HHS","NIH HHS"],"pagination":["13574-13593"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9620260"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["65(20)"],"pubmed_abstract":["Sialidases, or neuraminidases, are enzymes that catalyze the hydrolysis of sialic acid (Sia)-containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation, sialidase can modulate the functionality of the target compound and is thus often involved in biological pathways. Inhibition of sialidases with inhibitors is an important approach for understanding sialidase function and the underlying mechanisms and could serve as a therapeutic approach as well. Transition-state analogues, such as anti-influenza drugs oseltamivir and zanamivir, are major sialidase inhibitors. In addition, difluoro-sialic acids were developed as mechanism-based sialidase inhibitors. Further, fluorinated quinone methide-based suicide substrates were reported. Sialidase product analogue inhib"],"journal":["Journal of medicinal chemistry"],"pubmed_title":["Sialidase Inhibitors with Different Mechanisms."],"pmcid":["PMC9620260"],"funding_grant_id":["R15 GM144881","S10 OD025252","1R15GM144881-01"],"pubmed_authors":["Keil JM","Rafn GR","Aljohani MA","Sahebjam-Atabaki R","Turan IM","Sun XL"],"additional_accession":[]},"is_claimable":false,"name":"Sialidase Inhibitors with Different Mechanisms.","description":"Sialidases, or neuraminidases, are enzymes that catalyze the hydrolysis of sialic acid (Sia)-containing molecules, mostly removal of the terminal Sia (desialylation). By desialylation, sialidase can modulate the functionality of the target compound and is thus often involved in biological pathways. Inhibition of sialidases with inhibitors is an important approach for understanding sialidase function and the underlying mechanisms and could serve as a therapeutic approach as well. Transition-state analogues, such as anti-influenza drugs oseltamivir and zanamivir, are major sialidase inhibitors. In addition, difluoro-sialic acids were developed as mechanism-based sialidase inhibitors. Further, fluorinated quinone methide-based suicide substrates were reported. Sialidase product analogue inhib","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-04T22:32:19.667Z","creation":"2025-02-19T03:23:41.39Z"},"accession":"S-EPMC9620260","cross_references":{"pubmed":["36252951"],"doi":["10.1021/acs.jmedchem.2c01258"]}}