biostudies-literatureUnknownClarke KEN<h4>Background and objectives</h4>Trends in estimates of US pediatric SARS-CoV-2 infection-induced seroprevalence from commercial laboratory specimens may overrepresent children with frequent healthcare needs. We examined seroprevalence trends and compared seroprevalence estimates by testing type and diagnostic coding.<h4>Methods</h4>Cross-sectional convenience samples of residual sera between September 2021 and February 2022 from 52 U.S. jurisdictions were assayed for infection-induced SARS-CoV-2 antibodies; monthly seroprevalence estimates were calculated by age group. Multivariate logistic analyses compared seroprevalence estimates for specimens associated with ICD-10 codes and laboratory orders indicating well-child care with estimates for other pediatric specimens.<h4>Results</h4>InfeThe Journal of infectious diseasesjiac423https://www.ebi.ac.uk/biostudies/studies/S-EPMC9620360biostudies-literaturePediatric Infection-Induced SARS-CoV-2 Seroprevalence Increases and Seroprevalence by Type of Clinical Care-September 2021-February 2022.PMC9620360MacNeil AGundlapalli AVLee AJones JIachan RNycz EKim YHall AClarke KENDeng YfalsePediatric Infection-Induced SARS-CoV-2 Seroprevalence Increases and Seroprevalence by Type of Clinical Care-September 2021-February 2022.<h4>Background and objectives</h4>Trends in estimates of US pediatric SARS-CoV-2 infection-induced seroprevalence from commercial laboratory specimens may overrepresent children with frequent healthcare needs. We examined seroprevalence trends and compared seroprevalence estimates by testing type and diagnostic coding.<h4>Methods</h4>Cross-sectional convenience samples of residual sera between September 2021 and February 2022 from 52 U.S. jurisdictions were assayed for infection-induced SARS-CoV-2 antibodies; monthly seroprevalence estimates were calculated by age group. Multivariate logistic analyses compared seroprevalence estimates for specimens associated with ICD-10 codes and laboratory orders indicating well-child care with estimates for other pediatric specimens.<h4>Results</h4>Infe2022-01-01T00:00:00Z2022 Oct2025-04-05T11:57:17.4Z2025-02-19T03:59:25.305ZS-EPMC96203603628175710.1093/infdis/jiac423