biostudies-literatureKumar ANCI NIH HHS508-514https://www.ebi.ac.uk/biostudies/studies/S-EPMC9620550biostudies-literatureUnknown166(3)<h4>Objective</h4>We sought to determine the predictive value of combining tumor molecular subtype and computerized tomography (CT) imaging for surgical outcomes after primary cytoreductive surgery in advanced stage high-grade serous ovarian cancer (HGSOC) patients.<h4>Methods</h4>We identified 129 HGSOC patients who underwent pre-operative CT imaging and post-operative tumor mRNA profiling. A continuous CT-score indicative of overall disease burden was defined based on six imaging measurements of anatomic involvement. Molecular subtypes were derived from mRNA profiling of chemo-naïve tumors and classified as mesenchymal (MES) subtype (36%) or non-MES subtype (64%). Fischer exact tests and multivariate logistic regression examined residual disease and surgical complexity.<h4>Results</h4>WoGynecologic oncologyInto the future: A pilot study combining imaging with molecular profiling to predict resectability in ovarian cancer.PMC9620550R01 CA172404R01 CA248288Sheedy SPKim BWinham SJAnglesio MSWang CRamus SJTorres DMcCauley BMKeeney GLCliby WAKumar AGoode ELfalseInto the future: A pilot study combining imaging with molecular profiling to predict resectability in ovarian cancer.<h4>Objective</h4>We sought to determine the predictive value of combining tumor molecular subtype and computerized tomography (CT) imaging for surgical outcomes after primary cytoreductive surgery in advanced stage high-grade serous ovarian cancer (HGSOC) patients.<h4>Methods</h4>We identified 129 HGSOC patients who underwent pre-operative CT imaging and post-operative tumor mRNA profiling. A continuous CT-score indicative of overall disease burden was defined based on six imaging measurements of anatomic involvement. Molecular subtypes were derived from mRNA profiling of chemo-naïve tumors and classified as mesenchymal (MES) subtype (36%) or non-MES subtype (64%). Fischer exact tests and multivariate logistic regression examined residual disease and surgical complexity.<h4>Results</h4>Wo2022-01-01T00:00:00Z2022 Sep2025-04-04T09:41:48.097Z2025-04-04T09:41:48.097ZS-EPMC96205503593146810.1016/j.ygyno.2022.07.020