{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Currie SP"],"funding":["Medical Research Council","Wellcome Trust","Biotechnology and Biological Sciences Research Council","Engineering and Physical Sciences Research Council"],"pagination":["110801"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9620742"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["39(6)"],"pubmed_abstract":["Motor cortex generates descending output necessary for executing a wide range of limb movements. Although movement-related activity has been described throughout motor cortex, the spatiotemporal organization of movement-specific signaling in deep layers remains largely unknown. Here we record layer 5B population dynamics in the caudal forelimb area of motor cortex while mice perform a forelimb push/pull task and find that most neurons show movement-invariant responses, with a minority displaying movement specificity. Using cell-type-specific imaging, we identify that invariant responses dominate pyramidal tract (PT) neuron activity, with a small subpopulation representing movement type, whereas a larger proportion of intratelencephalic (IT) neurons display movement-type-specific signaling."],"journal":["Cell reports"],"pubmed_title":["Movement-specific signaling is differentially distributed across motor cortex layer 5 projection neuron classes."],"pmcid":["PMC9620742"],"funding_grant_id":["BB/R018537/1","MR/W004577/1","EP/V025449/1","110131/Z/15/Z","EP/X018466/1"],"pubmed_authors":["Ammer JJ","Dacre J","Clarke T","Mitchell L","Currie SP","Faisal AA","Premchand B","Duguid I","Wu Y","Colligan M","Eleftheriou C","Hennig MH"],"additional_accession":[]},"is_claimable":false,"name":"Movement-specific signaling is differentially distributed across motor cortex layer 5 projection neuron classes.","description":"Motor cortex generates descending output necessary for executing a wide range of limb movements. Although movement-related activity has been described throughout motor cortex, the spatiotemporal organization of movement-specific signaling in deep layers remains largely unknown. Here we record layer 5B population dynamics in the caudal forelimb area of motor cortex while mice perform a forelimb push/pull task and find that most neurons show movement-invariant responses, with a minority displaying movement specificity. Using cell-type-specific imaging, we identify that invariant responses dominate pyramidal tract (PT) neuron activity, with a small subpopulation representing movement type, whereas a larger proportion of intratelencephalic (IT) neurons display movement-type-specific signaling.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2026-07-14T15:21:01.203Z","creation":"2025-04-06T16:33:49.929Z"},"accession":"S-EPMC9620742","cross_references":{"pubmed":["35545038"],"doi":["10.1016/j.celrep.2022.110801"]}}