{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["29"],"submitter":["Kaufmann H"],"pubmed_abstract":["Giardiosis is a worldwide intestinal parasitosis, affecting both humans and animals. Treatment in dogs remains limited and the lack of efficacy of the few approved medications is a rising concern. In this study, 23 dogs raised by veterinary students and naturally infected with Giardia duodenalis were treated in home conditions with fenbendazole (50 mg/kg orally for 5 consecutive days). Fecal samples were collected immediately before treatment (FS1), 2-4 days after treatment (FS2) and 8-10 days after treatment (FS3). Giardia duodenalis cyst excretion was measured quantitatively by direct immunofluorescence assay (DFA) at FS1, FS2 and FS3. Molecular typing with a nested PCR targeting the SSU <sub>r</sub>DNA locus was also performed at FS1 and FS2. Fecal consistency improved in 16/21 dogs (76"],"journal":["Parasite (Paris, France)"],"pagination":["49"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9621113"],"repository":["biostudies-literature"],"pubmed_title":["Lack of efficacy of fenbendazole against Giardia duodenalis in a naturally infected population of dogs in France."],"pmcid":["PMC9621113"],"pubmed_authors":["Kaufmann H","Poirel MT","Zenner L","Bourgoin G","Benabed S"],"additional_accession":[]},"is_claimable":false,"name":"Lack of efficacy of fenbendazole against Giardia duodenalis in a naturally infected population of dogs in France.","description":"Giardiosis is a worldwide intestinal parasitosis, affecting both humans and animals. Treatment in dogs remains limited and the lack of efficacy of the few approved medications is a rising concern. In this study, 23 dogs raised by veterinary students and naturally infected with Giardia duodenalis were treated in home conditions with fenbendazole (50 mg/kg orally for 5 consecutive days). Fecal samples were collected immediately before treatment (FS1), 2-4 days after treatment (FS2) and 8-10 days after treatment (FS3). Giardia duodenalis cyst excretion was measured quantitatively by direct immunofluorescence assay (DFA) at FS1, FS2 and FS3. Molecular typing with a nested PCR targeting the SSU <sub>r</sub>DNA locus was also performed at FS1 and FS2. Fecal consistency improved in 16/21 dogs (76","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T07:45:24.319Z","creation":"2025-04-04T07:45:24.319Z"},"accession":"S-EPMC9621113","cross_references":{"pubmed":["36315102"],"doi":["10.1051/parasite/2022048"]}}