{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Strobl J"],"funding":["Austrian Science Fund FWF"],"pagination":["e161188"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9621130"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["132(21)"],"pubmed_abstract":["During cutaneous tick attachment, the feeding cavity becomes a site of transmission for tick salivary compounds and tick-borne pathogens. However, the immunological consequences of tick feeding for human skin remain unclear. Here, we assessed human skin and blood samples upon tick bite and developed a human skin explant model mimicking Ixodes ricinus bites and tick-borne pathogen infection. Following tick attachment, we observed rapidly occurring patterns of immunomodulation, including increases in neutrophils and cutaneous B and T cells. T cells upregulated tissue residency markers, while lymphocytic cytokine production was impaired. In early stages of Borrelia burgdorferi model infections, we detected strain-specific immune responses and close spatial relationships between macrophages an"],"journal":["The Journal of clinical investigation"],"pubmed_title":["Tick feeding modulates the human skin immune landscape to facilitate tick-borne pathogen transmission."],"pmcid":["PMC9621130"],"funding_grant_id":["P31494"],"pubmed_authors":["Berent S","Mundler V","Stanek G","Stockinger H","Muller S","Unterluggauer L","Kleissl L","Aguilar Gonzalez AE","Stary G","Gindl A","Strobl J","Staud C","Schotta AM","Redl A","Markowicz M","Weninger ST","Atzmuller D","Klasinc R"],"additional_accession":[]},"is_claimable":false,"name":"Tick feeding modulates the human skin immune landscape to facilitate tick-borne pathogen transmission.","description":"During cutaneous tick attachment, the feeding cavity becomes a site of transmission for tick salivary compounds and tick-borne pathogens. However, the immunological consequences of tick feeding for human skin remain unclear. Here, we assessed human skin and blood samples upon tick bite and developed a human skin explant model mimicking Ixodes ricinus bites and tick-borne pathogen infection. Following tick attachment, we observed rapidly occurring patterns of immunomodulation, including increases in neutrophils and cutaneous B and T cells. T cells upregulated tissue residency markers, while lymphocytic cytokine production was impaired. In early stages of Borrelia burgdorferi model infections, we detected strain-specific immune responses and close spatial relationships between macrophages an","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-26T20:44:10.456Z","creation":"2025-04-06T16:34:56.138Z"},"accession":"S-EPMC9621130","cross_references":{"pubmed":["36166299"],"doi":["10.1172/JCI161188"]}}