{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["15"],"submitter":["Liu R"],"pubmed_abstract":["<h4>Objective</h4>Altered expression patterns of Na<sup>+</sup>-K<sup>+</sup>-2Cl<sup>-</sup> (NKCC1) and K<sup>+</sup>-Cl<sup>-</sup> (KCC2) co-transporters have been implicated in the pathogenesis of epilepsy. Here, we assessed the effects of imbalanced NKCC1 and KCC2 on γ-aminobutyric acidergic (GABAergic) neurotransmission in certain brain regions involved in human focal cortical dysplasia (FCD).<h4>Materials and methods</h4>We sought to map a micro-macro neuronal network to better understand the epileptogenesis mechanism. In patients with FCD, we resected cortical tissue from the seizure the onset zone (SOZ) and the non-seizure onset zone (non-SOZ) inside the epileptogenic zone (EZ). Additionally, we resected non-epileptic neocortical tissue from the patients with mesial temporal lobe"],"journal":["Frontiers in molecular neuroscience"],"pagination":["954167"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9621392"],"repository":["biostudies-literature"],"pubmed_title":["Imbalance between the function of Na<sup>+</sup>-K<sup>+</sup>-2Cl and K<sup>+</sup>-Cl impairs Cl<sup>-</sup> homeostasis in human focal cortical dysplasia."],"pmcid":["PMC9621392"],"pubmed_authors":["Lai H","Zhang G","Li D","Xing Y","Zeng L","Zhang H","Loh HH","Xu C","Liu R","Wang J","Yan X","Yang X","Cheng L","Piao Y","Yu T"],"additional_accession":[]},"is_claimable":false,"name":"Imbalance between the function of Na<sup>+</sup>-K<sup>+</sup>-2Cl and K<sup>+</sup>-Cl impairs Cl<sup>-</sup> homeostasis in human focal cortical dysplasia.","description":"<h4>Objective</h4>Altered expression patterns of Na<sup>+</sup>-K<sup>+</sup>-2Cl<sup>-</sup> (NKCC1) and K<sup>+</sup>-Cl<sup>-</sup> (KCC2) co-transporters have been implicated in the pathogenesis of epilepsy. Here, we assessed the effects of imbalanced NKCC1 and KCC2 on γ-aminobutyric acidergic (GABAergic) neurotransmission in certain brain regions involved in human focal cortical dysplasia (FCD).<h4>Materials and methods</h4>We sought to map a micro-macro neuronal network to better understand the epileptogenesis mechanism. In patients with FCD, we resected cortical tissue from the seizure the onset zone (SOZ) and the non-seizure onset zone (non-SOZ) inside the epileptogenic zone (EZ). Additionally, we resected non-epileptic neocortical tissue from the patients with mesial temporal lobe","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T13:27:55.738Z","creation":"2025-04-05T13:27:55.738Z"},"accession":"S-EPMC9621392","cross_references":{"pubmed":["36324524"],"doi":["10.3389/fnmol.2022.954167"]}}