{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["33(17)"],"submitter":["Pang Y"],"pubmed_abstract":["<h4>Objective</h4>Epilepsy causes physical and mental damage to patients. As well known, microRNAs (miRNAs) provide therapeutic target potentials for patients with epilepsy. miR-128-3p was previously reported to be downregulated in temporal lobe epilepsy (TLE) patients, however, its detailed function in epilepsy is unknown.<h4>Methods</h4>Astrocytes function in epilepsy, penicillin-induced astrocytes can be used as a model for seizures in vitro. Currently, the expression levels of mitogen-activated protein kinase 6 (MAPK6), interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) were determined by western blot and reverse transcription-quantitative PCR analyses (RT-qPCR). The expression level of miR-128-3p was evaluated by RT-qPCR. TargetScan 7.1 and dual luciferase reporter ass"],"journal":["Neuroreport"],"pagination":["742-749"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9622368"],"repository":["biostudies-literature"],"pubmed_title":["miR-128-3p inhibits the inflammation by targeting MAPK6 in penicillin-induced astrocytes."],"pmcid":["PMC9622368"],"pubmed_authors":["Wang S","Pang Y","Luo D"],"additional_accession":[]},"is_claimable":false,"name":"miR-128-3p inhibits the inflammation by targeting MAPK6 in penicillin-induced astrocytes.","description":"<h4>Objective</h4>Epilepsy causes physical and mental damage to patients. As well known, microRNAs (miRNAs) provide therapeutic target potentials for patients with epilepsy. miR-128-3p was previously reported to be downregulated in temporal lobe epilepsy (TLE) patients, however, its detailed function in epilepsy is unknown.<h4>Methods</h4>Astrocytes function in epilepsy, penicillin-induced astrocytes can be used as a model for seizures in vitro. Currently, the expression levels of mitogen-activated protein kinase 6 (MAPK6), interleukin-1 beta (IL-1β) and tumor necrosis factor-alpha (TNF-α) were determined by western blot and reverse transcription-quantitative PCR analyses (RT-qPCR). The expression level of miR-128-3p was evaluated by RT-qPCR. TargetScan 7.1 and dual luciferase reporter ass","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T21:24:17.643Z","creation":"2025-04-04T21:24:17.643Z"},"accession":"S-EPMC9622368","cross_references":{"pubmed":["36250437"],"doi":["10.1097/WNR.0000000000001840"]}}