biostudies-literatureUnknown10(19)Wang Z<h4>Background</h4>Alzheimer's disease (AD) is the most common cause of dementia. Effective therapy, early diagnosis, and intervention are still lacking. Non-drug therapy and lifestyle interventions have become important means to prevent the occurrence and progression of AD, with nutritional therapy being one such example. Nutritional therapy, as a non-pharmacological intervention for AD, has made significant progress and shown significant promise for the development of treatment regimens in recent years. Niacin is a critical vitamin available in the forms of nicotinamide (NAM) and nicotinic acid (NA). In tissues, niacin is transformed into nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are involved in a variety of cellular processes. Annals of translational medicine1049https://www.ebi.ac.uk/biostudies/studies/S-EPMC9622504biostudies-literatureNicotinic acid supplementation contributes to the amelioration of Alzheimer's disease in mouse models.PMC9622504Zou ZLi QWang ZfalseNicotinic acid supplementation contributes to the amelioration of Alzheimer's disease in mouse models.<h4>Background</h4>Alzheimer's disease (AD) is the most common cause of dementia. Effective therapy, early diagnosis, and intervention are still lacking. Non-drug therapy and lifestyle interventions have become important means to prevent the occurrence and progression of AD, with nutritional therapy being one such example. Nutritional therapy, as a non-pharmacological intervention for AD, has made significant progress and shown significant promise for the development of treatment regimens in recent years. Niacin is a critical vitamin available in the forms of nicotinamide (NAM) and nicotinic acid (NA). In tissues, niacin is transformed into nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are involved in a variety of cellular processes. 2022-01-01T00:00:00Z2022 Oct2026-05-28T01:18:02.468Z2025-04-06T12:13:02.128ZS-EPMC96225043633041310.21037/atm-22-1148