{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Huang T"],"pubmed_abstract":["<h4>Background</h4>Low-voltage-substrate (LVS)-guided ablation for persistent atrial fibrillation (AF) has been described either in sinus rhythm (SR) or AF. Prolonged fractionated potentials (PFPs) may represent arrhythmogenic slow conduction substrate and potentially co-localize with LVS. We assess the spatial correlation of PFP identified in AF (PFP-AF) to those mapped in SR (PFP-SR). We further report the relationship between LVS and PFPs when mapped in AF or SR.<h4>Materials and methods</h4>Thirty-eight patients with ablation naïve persistent AF underwent left atrial (LA) high-density mapping in AF and SR prior to catheter ablation. Areas presenting PFP-AF and PFP-SR were annotated during mapping on the LA geometry. Low-voltage areas (LVA) were quantified using a bipolar threshold of 0"],"journal":["Frontiers in cardiovascular medicine"],"pagination":["1000027"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9622778"],"repository":["biostudies-literature"],"pubmed_title":["Validating left atrial fractionation and low-voltage substrate during atrial fibrillation and sinus rhythm-A high-density mapping study in persistent atrial fibrillation."],"pmcid":["PMC9622778"],"pubmed_authors":["Mayer L","Moreno Weidmann Z","Arentz T","Chen J","Lehrmann H","Jadidi A","Huang T","Westermann D","Muller-Edenborn B","Allgeier J","Schoechlin S","Eichenlaub M","Trenk D","Bohnen M"],"additional_accession":[]},"is_claimable":false,"name":"Validating left atrial fractionation and low-voltage substrate during atrial fibrillation and sinus rhythm-A high-density mapping study in persistent atrial fibrillation.","description":"<h4>Background</h4>Low-voltage-substrate (LVS)-guided ablation for persistent atrial fibrillation (AF) has been described either in sinus rhythm (SR) or AF. Prolonged fractionated potentials (PFPs) may represent arrhythmogenic slow conduction substrate and potentially co-localize with LVS. We assess the spatial correlation of PFP identified in AF (PFP-AF) to those mapped in SR (PFP-SR). We further report the relationship between LVS and PFPs when mapped in AF or SR.<h4>Materials and methods</h4>Thirty-eight patients with ablation naïve persistent AF underwent left atrial (LA) high-density mapping in AF and SR prior to catheter ablation. Areas presenting PFP-AF and PFP-SR were annotated during mapping on the LA geometry. Low-voltage areas (LVA) were quantified using a bipolar threshold of 0","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T02:35:55.817Z","creation":"2025-04-19T02:35:55.817Z"},"accession":"S-EPMC9622778","cross_references":{"pubmed":["36330001"],"doi":["10.3389/fcvm.2022.1000027"]}}