{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["43(11)"],"submitter":["Wang WD"],"pubmed_abstract":["The forkhead box M1 (FoxM1) protein, a transcription factor, plays critical roles in regulating tumor growth and drug resistance, while cellular FLICE-inhibitory protein (c-FLIP), an anti-apoptotic regulator, is involved in the ubiquitin-proteasome pathway. In this study, we investigated the effects of c-FLIP on the expression and ubiquitination levels of FoxM1 along with drug susceptibility in non-small-cell lung cancer (NSCLC) cells. We first showed that the expression levels of FoxM1 and c-FLIP were increased and positively correlated (R<sup>2</sup> = 0.1106, P < 0.0001) in 90 NSCLC samples. The survival data from prognostic analysis demonstrated that high expression of c-FLIP and/or FoxM1 was related to poor prognosis in NSCLC patients and that the combination of FoxM1 and c-FLIP could"],"journal":["Acta pharmacologica Sinica"],"pagination":["2956-2966"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9622852"],"repository":["biostudies-literature"],"pubmed_title":["c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression."],"pmcid":["PMC9622852"],"pubmed_authors":["Ni J","Chen SZ","Wang C","Wang AM","Shang Y","Li GJ","Su L","Wang WD"],"additional_accession":[]},"is_claimable":false,"name":"c-FLIP promotes drug resistance in non-small-cell lung cancer cells via upregulating FoxM1 expression.","description":"The forkhead box M1 (FoxM1) protein, a transcription factor, plays critical roles in regulating tumor growth and drug resistance, while cellular FLICE-inhibitory protein (c-FLIP), an anti-apoptotic regulator, is involved in the ubiquitin-proteasome pathway. In this study, we investigated the effects of c-FLIP on the expression and ubiquitination levels of FoxM1 along with drug susceptibility in non-small-cell lung cancer (NSCLC) cells. We first showed that the expression levels of FoxM1 and c-FLIP were increased and positively correlated (R<sup>2</sup> = 0.1106, P < 0.0001) in 90 NSCLC samples. The survival data from prognostic analysis demonstrated that high expression of c-FLIP and/or FoxM1 was related to poor prognosis in NSCLC patients and that the combination of FoxM1 and c-FLIP could","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-05-29T21:44:19.8Z","creation":"2025-05-29T21:44:19.8Z"},"accession":"S-EPMC9622852","cross_references":{"pubmed":["35422085"],"doi":["10.1038/s41401-022-00905-7"]}}