{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jamshidi N"],"funding":["National Center for Advancing Translational Sciences","NCATS NIH HHS","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["18308"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9622871"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["In vitro and in vivo studies have established the organic anion transporters OAT1 (SLC22A6, NKT) and OAT3 (SLC22A8) among the main multi-specific \"drug\" transporters. They also transport numerous endogenous metabolites, raising the possibility of drug-metabolite interactions (DMI). To help understand the role of these drug transporters on metabolism across scales ranging from organ systems to organelles, a formal multi-scale analysis was performed. Metabolic network reconstructions of the omics-alterations resulting from Oat1 and Oat3 gene knockouts revealed links between the microbiome and human metabolism including reactions involving small organic molecules such as dihydroxyacetone, alanine, xanthine, and p-cresol-key metabolites in independent pathways. Interestingly, pairwise organ-or"],"journal":["Scientific reports"],"pubmed_title":["Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions."],"pmcid":["PMC9622871"],"funding_grant_id":["R01GM132938","KL2TR001882","KL2 TR001882","R01 DK109392","R01DK109392","R01 GM132938"],"pubmed_authors":["Jamshidi N","Nigam SK"],"additional_accession":[]},"is_claimable":false,"name":"Drug transporters OAT1 and OAT3 have specific effects on multiple organs and gut microbiome as revealed by contextualized metabolic network reconstructions.","description":"In vitro and in vivo studies have established the organic anion transporters OAT1 (SLC22A6, NKT) and OAT3 (SLC22A8) among the main multi-specific \"drug\" transporters. They also transport numerous endogenous metabolites, raising the possibility of drug-metabolite interactions (DMI). To help understand the role of these drug transporters on metabolism across scales ranging from organ systems to organelles, a formal multi-scale analysis was performed. Metabolic network reconstructions of the omics-alterations resulting from Oat1 and Oat3 gene knockouts revealed links between the microbiome and human metabolism including reactions involving small organic molecules such as dihydroxyacetone, alanine, xanthine, and p-cresol-key metabolites in independent pathways. Interestingly, pairwise organ-or","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2026-05-03T10:53:53.421Z","creation":"2025-04-19T02:35:05.875Z"},"accession":"S-EPMC9622871","cross_references":{"pubmed":["36316339"],"doi":["10.1038/s41598-022-21091-w"]}}