biostudies-literatureUnknown12Jiang YJ<h4>Background</h4>The efficacy and safety of neoadjuvant chemotherapy (NAC) in treating resectable synchronous colorectal liver metastases (CRLM) remain controversial.<h4>Methods</h4>Data from CRLM patients who underwent simultaneous liver resection between January 2015 and December 2019 were collected from the Surveillance, Epidemiology, and End Results (SEER) database (SEER cohort, n=305) and a single Chinese Cancer Center (NCC cohort, n=268). Using a 1:2 ratio of propensity score matching (PSM), the prognostic impact of NAC for patients who underwent NAC before surgical treatment and patients who underwent surgical treatment alone was evaluated.<h4>Results</h4>After PSM, there was no significant difference in overall survival (OS) between patients receiving NAC prior to CRLM resection Frontiers in oncology951540https://www.ebi.ac.uk/biostudies/studies/S-EPMC9623041biostudies-literatureOncological outcomes of neoadjuvant chemotherapy in patients with resectable synchronous colorectal liver metastasis: A result from a propensity score matching study.PMC9623041Zhou SCChen JHLiang JWJiang YJfalseOncological outcomes of neoadjuvant chemotherapy in patients with resectable synchronous colorectal liver metastasis: A result from a propensity score matching study.<h4>Background</h4>The efficacy and safety of neoadjuvant chemotherapy (NAC) in treating resectable synchronous colorectal liver metastases (CRLM) remain controversial.<h4>Methods</h4>Data from CRLM patients who underwent simultaneous liver resection between January 2015 and December 2019 were collected from the Surveillance, Epidemiology, and End Results (SEER) database (SEER cohort, n=305) and a single Chinese Cancer Center (NCC cohort, n=268). Using a 1:2 ratio of propensity score matching (PSM), the prognostic impact of NAC for patients who underwent NAC before surgical treatment and patients who underwent surgical treatment alone was evaluated.<h4>Results</h4>After PSM, there was no significant difference in overall survival (OS) between patients receiving NAC prior to CRLM resection 2022-01-01T00:00:00Z20222025-04-19T02:37:55.388Z2025-04-07T13:01:58.505ZS-EPMC96230413633047910.3389/fonc.2022.951540