biostudies-literatureUnknown9Daniels S<h4>Background</h4>The incidence of thrombotic complications is high in COVID-19 patients with severe disease. As key regulators of thrombus formation, platelets likely play a crucial role as mediators of severe acute respiratory syndrome coronavirus 2 associated pathogenesis. Studies have reported that parameters reflecting platelet size, known as platelet volume indices (PVI), are raised in patients with thrombosis and can predict poor outcomes. This systematic review evaluates the potential for PVI to be used as a predictor of COVID-19 morbidity and mortality.<h4>Methods</h4>English and Chinese databases were searched electronically to identify studies reporting data on mean platelet volume, platelet distribution width or platelet-large cell ratio in COVID-19 patients. Included articlesFrontiers in cardiovascular medicine1031092https://www.ebi.ac.uk/biostudies/studies/S-EPMC9623063biostudies-literatureAre platelet volume indices of clinical use in COVID-19? A systematic review.PMC9623063van Tongeren MDenning DWWei HDaniels SfalseAre platelet volume indices of clinical use in COVID-19? A systematic review.<h4>Background</h4>The incidence of thrombotic complications is high in COVID-19 patients with severe disease. As key regulators of thrombus formation, platelets likely play a crucial role as mediators of severe acute respiratory syndrome coronavirus 2 associated pathogenesis. Studies have reported that parameters reflecting platelet size, known as platelet volume indices (PVI), are raised in patients with thrombosis and can predict poor outcomes. This systematic review evaluates the potential for PVI to be used as a predictor of COVID-19 morbidity and mortality.<h4>Methods</h4>English and Chinese databases were searched electronically to identify studies reporting data on mean platelet volume, platelet distribution width or platelet-large cell ratio in COVID-19 patients. Included articles2022-01-01T00:00:00Z20222025-04-19T02:37:56.6Z2025-02-19T00:47:25.801ZS-EPMC96230633632999910.3389/fcvm.2022.1031092