{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Romaniszyn M"],"funding":["Narodowe Centrum Nauki"],"pagination":["7722-7726"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9623593"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(42)"],"pubmed_abstract":["A novel organocatalytic reaction cascade between 3-cyano-4-styrylcoumarins and 2-mercaptoacetophenones is described. It is based on stereocontrolled functionalization of cyanocoumarins proceeding in a sequence of <i>thia</i>-Michael/aldol/annulation reactions. This highly diastereo- and enantioselective reaction is realized by employing enantioselective bifunctional catalysis and exhibits a broad substrate scope and excellent functional group tolerance. The synthetic application involves the transformation of the imidoester group, thus opening access to biologically relevant coumarin and δ-lactone-fused products."],"journal":["Organic letters"],"pubmed_title":["Organocatalytic Asymmetric Approach to γ,δ-Functionalization of 3-Cyano-4-styrylcoumarins via Bifunctional Catalysis."],"pmcid":["PMC9623593"],"funding_grant_id":["UMO-2015/18/E/ST5/00309"],"pubmed_authors":["Romaniszyn M","Dybowska J","Albrecht L","Skrzynska A"],"additional_accession":[]},"is_claimable":false,"name":"Organocatalytic Asymmetric Approach to γ,δ-Functionalization of 3-Cyano-4-styrylcoumarins via Bifunctional Catalysis.","description":"A novel organocatalytic reaction cascade between 3-cyano-4-styrylcoumarins and 2-mercaptoacetophenones is described. It is based on stereocontrolled functionalization of cyanocoumarins proceeding in a sequence of <i>thia</i>-Michael/aldol/annulation reactions. This highly diastereo- and enantioselective reaction is realized by employing enantioselective bifunctional catalysis and exhibits a broad substrate scope and excellent functional group tolerance. The synthetic application involves the transformation of the imidoester group, thus opening access to biologically relevant coumarin and δ-lactone-fused products.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-18T22:50:54.272Z","creation":"2025-04-07T10:32:55.131Z"},"accession":"S-EPMC9623593","cross_references":{"pubmed":["36252955"],"doi":["10.1021/acs.orglett.2c02836"]}}