biostudies-literatureUnknown13Tierney ALThe SARS-CoV-2 virus continues to cause significant morbidity and mortality worldwide from COVID-19. One of the major challenges of patient management is the broad range of symptoms observed. While the majority of individuals experience relatively mild disease, a significant minority of patients require hospitalisation, with COVID-19 still proving fatal for some. As such, there remains a desperate need to better understand what drives this severe disease, both in terms of the underlying biology, but also to potentially predict at diagnosis which patients are likely to require further interventions, thus enabling better outcomes for both patients and healthcare systems. Several lines of evidence have pointed to dysregulation of the complement cascade as a major factor in severe COVID-19 outFrontiers in immunology1032331https://www.ebi.ac.uk/biostudies/studies/S-EPMC9624227biostudies-literatureLevels of soluble complement regulators predict severity of COVID-19 symptoms.PMC9624227Allison JFurlong AKovalenko AGStark HPointon LDunmore BJTorok MEO'Brien CPhelan IPasquale CChinnery PKennet JOcaya CHughes RMartin JCossetti CHinch ADomingo JHuhn OHunter KChandler MHamilton WLBradley JROmarjee OJosipovic MPerales MPerera MWalker NHall GHein SMoulton ACalder JIvers TThaventhiran JYakovleva AEpping MFawke SDougan GKourampa JCurran MDPenkett CJMescia FRichoz NRees-Unwin KSGraf SSutcliffe RClapham-Riley DSummers CGeorgana IDe Sa AHosmillo MJones EJones HCruz IMeadows ALyons PAUnwin RDBooth LAlali WMCaddy SLTurner LSelvan MHosseini ZMcMahon CGupta RMuldoon FParmar SVargas PPrice JLinger RScholtes IFerreira ALehner PJTong ZKingston NParaschiv RBoston RFernandez Cde Jesus RGray JJose SWood JBermperi AIzuagbe RBaker SWorsley JMarsden JBradley JCaller LGCITIID-NIHR BioResource COVID-19 CollaborationPolgarova PBullman BHuang CRastall RRuffolo VWeekes MPWatson LGrenfell RPapadia SBergamashi LMendoza VHodgson JBiggs HSaunders CSmith KGCStrezlecki MCaputo DToshner MRTreacy CElmer ASavoinykh NSambrook JMulroney TJarvis IWylot MButcher HRanganath VTordesillas HSharma RTilly TRust MLi EWebster JJahun ASAlvio GClark SJRibeiro CTownsend PLewis DSpencer SBower GSchon KGurugama TRomashova NSage ACanna LKing YMeredith LWKhokhar FAHouldcroft CJDewhurst EGresley ELDi Stephano GHorner ECBrookes KPond NFeltwell TScott TCrucusio CBetancourt ALegchenko EChaudhry YHewitt SRowlands JGurugama LZerrudo JAStirrups KEWilliamson KKing RDempsey KPuc JCYTierney ALBucke AKasanicki MGoodfellow IMeloy SOvington NO'Donnell CShih JPinckert MLVergese BFuller SCooper DMatheson NJHarris JGraves BBeristain-Covarrubias NfalseLevels of soluble complement regulators predict severity of COVID-19 symptoms.The SARS-CoV-2 virus continues to cause significant morbidity and mortality worldwide from COVID-19. One of the major challenges of patient management is the broad range of symptoms observed. While the majority of individuals experience relatively mild disease, a significant minority of patients require hospitalisation, with COVID-19 still proving fatal for some. As such, there remains a desperate need to better understand what drives this severe disease, both in terms of the underlying biology, but also to potentially predict at diagnosis which patients are likely to require further interventions, thus enabling better outcomes for both patients and healthcare systems. Several lines of evidence have pointed to dysregulation of the complement cascade as a major factor in severe COVID-19 out2022-01-01T00:00:00Z20222025-04-19T02:35:32.781Z2025-04-19T02:35:32.781ZS-EPMC96242273633052610.3389/fimmu.2022.1032331