{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Melchinger H"],"funding":["NCATS NIH HHS","NIDDK NIH HHS","National Institute of Diabetes and Digestive and Kidney Diseases"],"pagination":["1284-1292"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9625093"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(9)"],"pubmed_abstract":["<h4>Background and objectives</h4>Uromodulin, produced exclusively in the kidney's thick ascending limb, is a biomarker of kidney tubular health. However, the relationship between urine uromodulin and histologic changes in the kidney tubulointerstitium has not been characterized. In this study, we test the association of urine uromodulin with kidney histologic findings in humans and mice.<h4>Design, setting, participants, & measurements</h4>We investigated the independent association of urine uromodulin measured at the time of kidney biopsy with histologic features in 364 participants at two academic medical centers from 2015 to 2018 using multivariable linear regression models. This relationship was further examined by comparison of uromodulin staining in murine models of kidney fibrosis "],"journal":["Clinical journal of the American Society of Nephrology : CJASN"],"pubmed_title":["Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis."],"pmcid":["PMC9625093"],"funding_grant_id":["K01DK120783","K23 DK117065","UH3 DK114866","R01 DK126815","R01DK128087","UL1 TR001863","R01 DK128087","K23DK117065","UH3DK114866","P30 DK079310","P30DK079310","R01DK126815","K01 DK120783"],"pubmed_authors":["Xu L","Calderon-Gutierrez F","Parikh CR","Obeid W","Moeckel GW","Kashgarian M","Wilson FP","Luciano RL","Melchinger H","Kuperman M","Moledina DG","Shaw MM"],"additional_accession":[]},"is_claimable":false,"name":"Urine Uromodulin as a Biomarker of Kidney Tubulointerstitial Fibrosis.","description":"<h4>Background and objectives</h4>Uromodulin, produced exclusively in the kidney's thick ascending limb, is a biomarker of kidney tubular health. However, the relationship between urine uromodulin and histologic changes in the kidney tubulointerstitium has not been characterized. In this study, we test the association of urine uromodulin with kidney histologic findings in humans and mice.<h4>Design, setting, participants, & measurements</h4>We investigated the independent association of urine uromodulin measured at the time of kidney biopsy with histologic features in 364 participants at two academic medical centers from 2015 to 2018 using multivariable linear regression models. This relationship was further examined by comparison of uromodulin staining in murine models of kidney fibrosis ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Sep","modification":"2025-04-04T22:54:52.992Z","creation":"2025-04-04T22:54:52.992Z"},"accession":"S-EPMC9625093","cross_references":{"pubmed":["35948365"],"doi":["10.2215/CJN.04360422","10.2215/cjn.04360422"]}}