{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["122(11)"],"submitter":["Planquette B"],"funding":["Groupe Hospitalier Paris Saint Joseph"],"pubmed_abstract":["<h4>Objective</h4> D-dimer measurement is a safe tool to exclude pulmonary embolism (PE), but its specificity decreases in coronavirus disease 2019 (COVID-19) patients. Our aim was to derive a new algorithm with a specific D-dimer threshold for COVID-19 patients.<h4>Methods</h4> We conducted a French multicenter, retrospective cohort study among 774 COVID-19 patients with suspected PE. D-dimer threshold adjusted to extent of lung damage found on computed tomography (CT) was derived in a patient set (<i>n</i> = 337), and its safety assessed in an independent validation set (<i>n</i> = 337).<h4>Results</h4> According to receiver operating characteristic curves, in the derivation set, D-dimer safely excluded PE, with one false negative, when using a 900 ng/mL threshold when lung damage extent"],"journal":["Thrombosis and haemostasis"],"pagination":["1888-1898"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9626028"],"repository":["biostudies-literature"],"pubmed_title":["Adjusting D-dimer to Lung Disease Extent to Exclude Pulmonary Embolism in COVID-19 Patients (Co-LEAD)."],"pmcid":["PMC9626028"],"pubmed_authors":["Soudet S","Goudot G","Sanchez O","Rance B","Emmerich J","Mirault T","Meneveau N","Fournier L","Chatellier G","Berre AL","Sevestre MA","Mao RL","Gendron N","Besutti M","Hamoud AA","Kahf SA","Couturaud F","Messas E","Yanoutsos A","Planquette B","Smadja DM","Chocron R","Khider L","Pernod G","Philippe A","Ferretti G","Diehl JL","Mohamedi N"],"additional_accession":[]},"is_claimable":false,"name":"Adjusting D-dimer to Lung Disease Extent to Exclude Pulmonary Embolism in COVID-19 Patients (Co-LEAD).","description":"<h4>Objective</h4> D-dimer measurement is a safe tool to exclude pulmonary embolism (PE), but its specificity decreases in coronavirus disease 2019 (COVID-19) patients. Our aim was to derive a new algorithm with a specific D-dimer threshold for COVID-19 patients.<h4>Methods</h4> We conducted a French multicenter, retrospective cohort study among 774 COVID-19 patients with suspected PE. D-dimer threshold adjusted to extent of lung damage found on computed tomography (CT) was derived in a patient set (<i>n</i> = 337), and its safety assessed in an independent validation set (<i>n</i> = 337).<h4>Results</h4> According to receiver operating characteristic curves, in the derivation set, D-dimer safely excluded PE, with one false negative, when using a 900 ng/mL threshold when lung damage extent","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2025-04-25T19:35:01.841Z","creation":"2025-04-06T08:01:37.837Z"},"accession":"S-EPMC9626028","cross_references":{"pubmed":["35144305"],"doi":["10.1055/a-1768-4371"]}}