biostudies-literatureUnknown122(11)Planquette BGroupe Hospitalier Paris Saint Joseph<h4>Objective</h4> D-dimer measurement is a safe tool to exclude pulmonary embolism (PE), but its specificity decreases in coronavirus disease 2019 (COVID-19) patients. Our aim was to derive a new algorithm with a specific D-dimer threshold for COVID-19 patients.<h4>Methods</h4> We conducted a French multicenter, retrospective cohort study among 774 COVID-19 patients with suspected PE. D-dimer threshold adjusted to extent of lung damage found on computed tomography (CT) was derived in a patient set (<i>n</i> = 337), and its safety assessed in an independent validation set (<i>n</i> = 337).<h4>Results</h4> According to receiver operating characteristic curves, in the derivation set, D-dimer safely excluded PE, with one false negative, when using a 900 ng/mL threshold when lung damage extentThrombosis and haemostasis1888-1898https://www.ebi.ac.uk/biostudies/studies/S-EPMC9626028biostudies-literatureAdjusting D-dimer to Lung Disease Extent to Exclude Pulmonary Embolism in COVID-19 Patients (Co-LEAD).PMC9626028Soudet SGoudot GSanchez ORance BEmmerich JMirault TMeneveau NFournier LChatellier GBerre ALSevestre MAMao RLGendron NBesutti MHamoud AAKahf SACouturaud FMessas EYanoutsos APlanquette BSmadja DMChocron RKhider LPernod GPhilippe AFerretti GDiehl JLMohamedi NfalseAdjusting D-dimer to Lung Disease Extent to Exclude Pulmonary Embolism in COVID-19 Patients (Co-LEAD).<h4>Objective</h4> D-dimer measurement is a safe tool to exclude pulmonary embolism (PE), but its specificity decreases in coronavirus disease 2019 (COVID-19) patients. Our aim was to derive a new algorithm with a specific D-dimer threshold for COVID-19 patients.<h4>Methods</h4> We conducted a French multicenter, retrospective cohort study among 774 COVID-19 patients with suspected PE. D-dimer threshold adjusted to extent of lung damage found on computed tomography (CT) was derived in a patient set (<i>n</i> = 337), and its safety assessed in an independent validation set (<i>n</i> = 337).<h4>Results</h4> According to receiver operating characteristic curves, in the derivation set, D-dimer safely excluded PE, with one false negative, when using a 900 ng/mL threshold when lung damage extent2022-01-01T00:00:00Z2022 Nov2025-04-25T19:35:01.841Z2025-04-06T08:01:37.837ZS-EPMC96260283514430510.1055/a-1768-4371